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    Ubqn Ubiquilin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32977, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ubqnprovided by FlyBase
    Official Full Name
    Ubiquilinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031057
    Locus tag
    Dmel_CG14224
    See related
    AllianceGenome:FB:FBgn0031057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-18DEa; BEST:LD26923; CG14224; Chap; clone 5.42; Dmel\CG14224; dsk2; Dsk2; DSK2; dUbqln; dUbqn; UBQLN; UBQLN homolog; UBQLN1; ubqn
    Summary
    Enables proteasome binding activity. Involved in amyloid precursor protein metabolic process and ubiquitin-dependent protein catabolic process. Located in cytosol. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut; larval muscle system; and larval nervous system. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 15; frontotemporal dementia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to human UBQLN1 (ubiquilin 1); UBQLN2 (ubiquilin 2); and UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ubqn in Genome Data Viewer
    Location:
    18E1-18E1; 1-64 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19683808..19687658)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19577841..19581691)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Zwischenferment Neighboring gene eye transformer Neighboring gene domeless Neighboring gene uncharacterized protein Neighboring gene Merlin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits. Jantrapirom S, et al. Sci Rep, 2020 Mar 30. PMID 32231214, Free PMC Article
    2. Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer's Disease Both in vitro and in vivo. Zhang C, et al. Front Neurosci, 2022. PMID 35401099, Free PMC Article
    3. Honeybee products and edible insect powders improve locomotive and learning abilities of Ubiquilin-knockdown Drosophila. Phokasem P, et al. BMC Complement Med Ther, 2020 Aug 31. PMID 32867756, Free PMC Article
    4. A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities. Jantrapirom S, et al. Exp Cell Res, 2018 Jan 15. PMID 29247619
    5. Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly. Jantrapirom S, et al. Biochim Biophys Acta Mol Basis Dis, 2018 Sep. PMID 29936333

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate a role for ubiquilins as regulators of autophagy by controlling mTOR serine-threonine kinases (mTOR)signalling.
      Title: Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
    2. Study demonstrated that the depletion of dUbqn markedly affected the expression and sub-cellular localization of Drosophila TDP-43 (TBPH), resulting in a cytoplasmic ubiquitin-positive TBPH pathology.
      Title: Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly.
    3. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities. We herein performed a phenotypic and molecular characterization of diverse dUbqn RNAi lines
      Title: A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
    4. Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and proper Ubiquilin levels, preventing postsynaptic proteins from accumulation to confine postsynaptic growth.
      Title: USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin.
    5. overexpression of Dsk2 caused severe morphological abnormalities in the late pupal stages, leading to pharate adult lethality, accompanied by a huge accumulation of highly polyubiquitylated proteins.
      Title: Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.
    6. Study shows that Drosophila Ubiquilin (Ubqn) binds to Drosophila Presenilin (Psn), and that loss of ubqn function suppresses phenotypes that arise from loss of psn function in vivo.
      Title: ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amyloid precursor protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquilin
    Names
    CG14224-PA
    CG14224-PB
    Ubqn-PA
    Ubqn-PB
    ubiquilin 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19683808..19687658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298528.1 → NP_001285457.1  ubiquilin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWD9
      Conserved Domains (4) summary
      smart00727
      Location:322 → 368
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:9 → 79
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:9 → 79
      UBQ; Ubiquitin homologues
      cd14399
      Location:501 → 537
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    2. NM_134500.4 → NP_608344.1  ubiquilin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWD9
      Related
      FBpp0074519
      Conserved Domains (4) summary
      smart00727
      Location:322 → 368
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:9 → 79
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:9 → 79
      UBQ; Ubiquitin homologues
      cd14399
      Location:501 → 537
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWD9 Q9VWD9

    Gene LinkOut

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