esg escargot [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: esgprovided by FlyBase
Official Full Name: escargotprovided by FlyBase
Primary source: FLYBASE:FBgn0287768
Locus tag: Dmel_CG3758
See related: AllianceGenome:FB:FBgn0287768
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4B7; BG01042; BG:DS07851.7; br43; CG3758; dgl; Dmel\CG3758; Esg; flg; l(2)07082; l(2)35Ce; l(2)4B7; l(2)br43; l(2)esg; l35Ce; shof; wiz
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; open tracheal system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic imaginal tissue; epithelium; gut section; larval imaginal tissue; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35D2-35D2; 2-51 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15333866..15336138)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15333866..15336138)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
Title: Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model.
Title: Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model.
Results show that both Esg and Sc bind to a common promoter region of pros. Moreover, antagonistic activity between Esg and Sc controls the expression status of Pros in stem cells, thereby, specifying whether stem cells remain undifferentiated or commit to enteroendocrine cell differentiation.
Title: Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells.
Esg controls specification of cell types in trachea and suppresses ERK signaling in fusion cells to control cells' differential migratory behavior.
Title: Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila.
Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs
Title: Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs.
CySCs mutant for esg are not maintained as stem cells, but remain capable of differentiating normally along the cyst cell lineage. In contrast, esg mutant CySCs that give rise to a closely related lineage, the apical hub cells, cannot maintain hub cell identity. this dual regulatory role is due to simultaneous control by Esg of overlapping genetic programs. Similar results were obtained with intestinal stem cells.
Title: Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart?
Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.
Title: Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.
Cell type-specific transcriptome analysis combined with Dam-ID binding studies identified Esg as a major repressor of differentiation genes in stem and progenitor cells.
Title: Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells.
Authors demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through modulation of Notch activity.
Title: Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.
Escargot protein as an essential factor is required in hub cells for maintaining niche integrity by blocking conversion of hub cells to the cyst cell lineage.
Title: Escargot restricts niche cell to stem cell conversion in the Drosophila testis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0011 (e-PCR)
- UniSTS:17946

Dm0348 (e-PCR)
- UniSTS:35124

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of imaginal histoblast diploidy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of compound eye pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: escargot

Names: CG3758-PA; D.m.Escargot; Fusion-1; double glazed; esg-PA; esgargot; fleabag; shut off; wizard

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15333866..15336138

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057252.4 → NP_476600.1 escargot [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476600.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P25932, Q8SYF2, Q9V3E1

UniProtKB/TrEMBL

H9ZJM4

Related

FBpp0080293

Conserved Domains (4) summary

sd00017
Location:372 → 392

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:311 → 331

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:398 → 420

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:385 → 408

zf-H2C2_2; Zinc-finger double domain