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    CG3740 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3740provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023530
    Locus tag
    Dmel_CG3740
    See related
    AllianceGenome:FB:FBgn0023530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    dC19orf12; Dmel\CG3740; EG:171E4.4
    Summary
    Involved in neuromuscular process. Is expressed in adult abdomen; adult head; adult thorax; and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 43 and neurodegeneration with brain iron accumulation 4. Orthologous to human C19orf12 (chromosome 19 open reading frame 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3740 in Genome Data Viewer
    Location:
    2B5-2B5; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1668406..1669297, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1562439..1563330, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mucin related 2B Neighboring gene small non-coding RNA 400 Neighboring gene broad Neighboring gene uncharacterized protein Neighboring gene deep orange Neighboring gene halfway Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration. Iuso A, et al. PLoS One, 2014. PMID 24586779, Free PMC Article
    2. Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. Mori A, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31548400, Free PMC Article
    3. Nazo, the Drosophila homolog of the NBIA-mutated protein-c19orf12, is required for triglyceride homeostasis. Sreejith P, et al. PLoS Genet, 2024 Feb. PMID 38335241, Free PMC Article
    4. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Benos PV, et al. Science, 2000 Mar 24. PMID 10731137
    5. Molecular characterization of the singed wings locus of Drosophila melanogaster. Schwartz YB, et al. BMC Genet, 2004 Jun 9. PMID 15189568, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3740-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1668406..1669297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130576.4 → NP_569932.1  uncharacterized protein Dmel_CG3740 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W569
      Related
      FBpp0070273
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46063 O46063
    Q9W569 Q9W569

    Gene LinkOut

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