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    kin17 kin17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kin17provided by FlyBase
    Official Full Name
    kin17provided by FlyBase
    Primary source
    FLYBASE:FBgn0024887
    Locus tag
    Dmel_CG5649
    See related
    AllianceGenome:FB:FBgn0024887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5649; Dmel\CG5649; Kin17
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in DNA damage response and DNA replication. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human KIN (Kin17 DNA and RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kin17 in Genome Data Viewer
    Location:
    77B5-77B5; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20356807..20358331)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20349907..20351431)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Retinoblastoma binding protein 5 Neighboring gene eukaryotic translation release factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA primase subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression. Connell M, et al. Cell Rep, 2024 Mar 26. PMID 38386552, Free PMC Article
    2. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. Parkhitko AA, et al. PLoS Genet, 2021 Feb. PMID 33591981, Free PMC Article
    3. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
    4. Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Herold N, et al. Mol Cell Biol, 2009 Jan. PMID 18981222, Free PMC Article
    5. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
      Title: Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    kin17
    Names
    CG5649-PA
    kin17-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20356807..20358331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140955.4 → NP_649212.2  kin17 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649212.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXR2, Q9VPH4
      Related
      FBpp0077839
      Conserved Domains (2) summary
      cd13155
      Location:336 → 387
      KOW_KIN17; KOW_Kin17 is a RNA-binding motif
      pfam10357
      Location:55 → 177
      Kin17_mid; Domain of Kin17 curved DNA-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76926 O76926
    Q8SXR2 Q8SXR2
    Q9VPH4 Q9VPH4

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