DTX4 deltex E3 ubiquitin ligase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DTX4provided by HGNC
Official Full Name: deltex E3 ubiquitin ligase 4provided by HGNC
Primary source: HGNC:HGNC:29151
See related: Ensembl:ENSG00000110042 MIM:616110; AllianceGenome:HGNC:29151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF155
Summary: Enables ubiquitin protein ligase activity. Involved in negative regulation of innate immune response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Is active in centrosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (59171430..59208588)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (59120605..59157761)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (58938903..58976061)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1.
Title: Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1.
Notch is ligand activated and undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing
Title: Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing.
Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation.
Title: NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of deltex homolog 4 (DTX4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T98251 (e-PCR)
- UniSTS:42020

G19706 (e-PCR)
- UniSTS:58921

A001W11 (e-PCR)
- UniSTS:58922

WI-20048 (e-PCR)
- UniSTS:31285

RH16197 (e-PCR)
- UniSTS:4233

D11S1176 (e-PCR)
- UniSTS:57252

SHGC-172592 (e-PCR)
- UniSTS:182484

SHGC-34178 (e-PCR)
- UniSTS:79860

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type I interferon production	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase DTX4

Names: RING finger protein 155; RING-type E3 ubiquitin transferase DTX4; deltex 4 homolog; deltex 4, E3 ubiquitin ligase; deltex homolog 4; deltex4; protein deltex-4

NP_001287656.1

EC 2.3.2.27

NP_055992.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300727.2 → NP_001287656.1 E3 ubiquitin-protein ligase DTX4 isoform 2

See identical proteins and their annotated locations for NP_001287656.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AP002358, BC119011

Consensus CDS

CCDS76408.1

UniProtKB/Swiss-Prot

Q9Y2E6

Related

ENSP00000434055.1, ENST00000532982.5

Conserved Domains (4) summary

cd09633
Location:370 → 502

Deltex_C; Domain found at the C-terminus of deltex-like

pfam02825
Location:1 → 38

WWE; WWE domain

cd16671
Location:300 → 366

RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins

cl26464
Location:63 → 259

Atrophin-1; Atrophin-1 family
NM_015177.2 → NP_055992.1 E3 ubiquitin-protein ligase DTX4 isoform 1

See identical proteins and their annotated locations for NP_055992.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB023154, AP001258, AP002358, BF195769

Consensus CDS

CCDS44612.1

UniProtKB/Swiss-Prot

Q0VF38, Q9Y2E6

Related

ENSP00000227451.3, ENST00000227451.4

Conserved Domains (4) summary

smart00678
Location:8 → 86

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd09633
Location:476 → 608

Deltex_C; Domain found at the C-terminus of deltex-like

cd00162
Location:408 → 469

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam02825
Location:90 → 144

WWE; WWE domain