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    Dynlrb1 dynein light chain roadblock-type 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170714, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dynlrb1provided by RGD
    Official Full Name
    dynein light chain roadblock-type 1provided by RGD
    Primary source
    RGD:619910
    See related
    EnsemblRapid:ENSRNOG00000025715 AllianceGenome:RGD:619910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    km23; Dncl2a
    Summary
    Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Involved in visual behavior. Located in cytoplasm. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 746.8), Brain (RPKM 696.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dynlrb1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164197892..164224409)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143742427..143764227)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150761329..150782493)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12, pseudogene 7 Neighboring gene uncharacterized LOC102549926 Neighboring gene itchy E3 ubiquitin protein ligase Neighboring gene U2 spliceosomal RNA Neighboring gene microtubule-associated protein 1 light chain 3 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Light-induced down-regulation of the rat class 1 dynein-associated protein robl/LC7-like gene in visual cortex. Ye F, et al. J Biol Chem, 2000 Sep 1. PMID 10816553
    2. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Islam MA, et al. Exp Mol Med, 2015 Aug 14. PMID 26272270, Free PMC Article
    3. The Roadblock light chains are ubiquitous components of cytoplasmic dynein that form homo- and heterodimers. Nikulina K, et al. Cell Motil Cytoskeleton, 2004 Apr. PMID 14752807
    4. Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients. Jiang J, et al. Gene, 2001 Dec 27. PMID 11750132
    5. Cytoplasmic dynein. Allan VJ. Biochem Soc Trans, 2011 Oct. PMID 21936784

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points.
      Title: N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in retrograde axonal transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in visual behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic dynein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain roadblock-type 1
    Names
    BLP
    bithoraxoid-like protein
    dynein light chain 2A, cytoplasmic
    dynein, cytoplasmic, light chain 2A
    dynein-associated protein Km23
    dynein-associated protein RKM23
    robl/LC7-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131910.5 → NP_571985.1  dynein light chain roadblock-type 1

      See identical proteins and their annotated locations for NP_571985.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62628
      UniProtKB/TrEMBL
      A0A8I6A1D3, A6KI20
      Related
      ENSRNOP00000110838.1, ENSRNOT00000122357.1
      Conserved Domains (1) summary
      smart00960
      Location:4 → 91
      Robl_LC7; Roadblock/LC7 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164197892..164224409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283030.1 → XP_063139100.1  dynein light chain roadblock-type 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2M7
      Related
      ENSRNOP00000085894.1, ENSRNOT00000106591.2

    2. XM_039104174.2 → XP_038960102.1  dynein light chain roadblock-type 1 isoform X2

      Conserved Domains (1) summary
      smart00960
      Location:23 → 95
      Robl_LC7; Roadblock/LC7 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62628.3 GenPept UniProtKB/Swiss-Prot:P62628

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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