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    NIBAN3 niban apoptosis regulator 3 [ Homo sapiens (human) ]

    Gene ID: 199786, updated on 27-Nov-2024

    Summary

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    Official Symbol
    NIBAN3provided by HGNC
    Official Full Name
    niban apoptosis regulator 3provided by HGNC
    Primary source
    HGNC:HGNC:24130
    See related
    Ensembl:ENSG00000167483 MIM:609967; AllianceGenome:HGNC:24130
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCNP1; FAM129C
    Expression
    Biased expression in spleen (RPKM 12.1), lymph node (RPKM 9.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NIBAN3 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17523301..17555537)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17657937..17690155)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17634110..17664652)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17581949-17582450 Neighboring gene Sharpr-MPRA regulatory region 2801 Neighboring gene solute carrier family 27 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17593839-17594340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14275 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17599959-17600122 Neighboring gene PGLS divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17609403-17609947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17610300-17611168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17611169-17612037 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:17618299-17619498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17621304-17621961 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17621962-17622618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10350 Neighboring gene Sharpr-MPRA regulatory region 7913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17623276-17623931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14278 Neighboring gene 6-phosphogluconolactonase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17641583-17642201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10355 Neighboring gene collagen beta(1-O)galactosyltransferase 1 Neighboring gene Sharpr-MPRA regulatory region 8704 Neighboring gene ribosomal protein L21 pseudogene 130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer. Patel SJ, et al. J Cell Mol Med, 2017 Mar. PMID 27680505, Free PMC Article
    2. Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. Boyd RS, et al. Leukemia, 2003 Aug. PMID 12886250
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI3K inhibition and p38 MAPK activation leads to reduction in phosphorylation of BCNP1 at serine residues.
      Title: The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer.
    2. Isolation and sequencing. Prediction of transmembrane domains, with three alternatively spliced final exons.
      Title: Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39802

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Niban 3
    Names
    B-cell novel protein 1
    family with sequence similarity 129 member C
    niban-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098524.2 → NP_001091994.2  protein Niban 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC010618
      Consensus CDS
      CCDS42521.1
      UniProtKB/TrEMBL
      Q8N894
      Related
      ENSP00000333447.4, ENST00000332386.9

    2. NM_001321826.2 → NP_001308755.2  protein Niban 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC010618
      Consensus CDS
      CCDS82315.1
      UniProtKB/TrEMBL
      B4DT44, M0R0E0
      Related
      ENSP00000471168.1, ENST00000601861.5

    3. NM_001321827.2 → NP_001308756.2  protein Niban 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC010618
      Consensus CDS
      CCDS82314.1
      UniProtKB/TrEMBL
      M0QXK3, Q8N894
      Related
      ENSP00000469225.1, ENST00000599164.6

    4. NM_001321828.1 → NP_001308757.1  protein Niban 3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC010618, AI688885, AK298062, AY254198
      Consensus CDS
      CCDS82317.1
      UniProtKB/Swiss-Prot
      Q86XR2
      Related
      ENSP00000394929.2, ENST00000449408.6

    5. NM_001363609.1 → NP_001350538.1  protein Niban 3 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010618, AK097121, AY254198
      Consensus CDS
      CCDS86723.1
      UniProtKB/TrEMBL
      M0QZV9, Q8N894
      Related
      ENSP00000470798.1, ENST00000599124.1

    6. NM_173544.5 → NP_775815.3  protein Niban 3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC010618
      Consensus CDS
      CCDS12362.1
      UniProtKB/Swiss-Prot
      B4DNU3, B4DVN7, Q7Z6H6, Q86XR2, Q86XR3, Q86XR4, Q8TEQ3
      UniProtKB/TrEMBL
      B4DT44
      Related
      ENSP00000335040.3, ENST00000335393.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      17523301..17555537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527786.3 → XP_011526088.1  protein Niban 3 isoform X5

      UniProtKB/TrEMBL
      Q8N894

    2. XM_017026453.2 → XP_016881942.1  protein Niban 3 isoform X1

      UniProtKB/TrEMBL
      B4DT44

    3. XM_017026454.2 → XP_016881943.1  protein Niban 3 isoform X2

    4. XM_047438389.1 → XP_047294345.1  protein Niban 3 isoform X8

    5. XM_011527781.4 → XP_011526083.1  protein Niban 3 isoform X3

      UniProtKB/TrEMBL
      Q8N894

    6. XM_011527787.4 → XP_011526089.1  protein Niban 3 isoform X6

      UniProtKB/TrEMBL
      M0QX95
      Related
      ENSP00000468994.1, ENST00000600519.5

    7. XM_047438390.1 → XP_047294346.1  protein Niban 3 isoform X9

    8. XM_011527789.2 → XP_011526091.1  protein Niban 3 isoform X7

      UniProtKB/TrEMBL
      M0QX95

    9. XM_017026457.2 → XP_016881946.1  protein Niban 3 isoform X8

    10. XM_047438388.1 → XP_047294344.1  protein Niban 3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17657937..17690155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320168.1 → XP_054176143.1  protein Niban 3 isoform X5

    2. XM_054320164.1 → XP_054176139.1  protein Niban 3 isoform X1

    3. XM_054320165.1 → XP_054176140.1  protein Niban 3 isoform X2

    4. XM_054320171.1 → XP_054176146.1  protein Niban 3 isoform X8

    5. XM_054320166.1 → XP_054176141.1  protein Niban 3 isoform X3

    6. XM_054320169.1 → XP_054176144.1  protein Niban 3 isoform X6

    7. XM_054320173.1 → XP_054176148.1  protein Niban 3 isoform X9

    8. XM_054320170.1 → XP_054176145.1  protein Niban 3 isoform X7

    9. XM_054320172.1 → XP_054176147.1  protein Niban 3 isoform X8

    10. XM_054320167.1 → XP_054176142.1  protein Niban 3 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XR2.2 GenPept UniProtKB/Swiss-Prot:Q86XR2

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