Mapre1 microtubule-associated protein, RP/EB family, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapre1provided by RGD
Official Full Name: microtubule-associated protein, RP/EB family, member 1provided by RGD
Primary source: RGD:621781
See related: EnsemblRapid:ENSRNOG00000011798 AllianceGenome:RGD:621781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eb1
Summary: Enables microtubule plus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to microtubule cytoskeleton; and regulation of microtubule polymerization. Predicted to act upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be located in several cellular components, including cell projection membrane; focal adhesion; and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 344.9), Spleen (RPKM 300.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (162679020..162707167)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (142218846..142246990)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (149221346..149249469)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.
Title: NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.
provides a functional link between tubulin- and actin-based cytoskeletons to confer spermatocyte transport at the blood-testis barrier
Title: EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study.
the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
EB3 and EB1 coordinate a molecular and functional interplay between ankyrin G (ankG)and the axon initial segment microtubules that supports the central role of ankG in the maintenance of neuronal polarity
Title: End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment.
In this study we used EB1 immunostaining in mitotic NRK-52E cells to quantitatively analyse the length and number of growing astral microtubules during metaphase and anaphase
Title: EB 1 immunofluorescence reveals an increase in growing astral microtubule length and number during anaphase in NRK-52E cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128960 (e-PCR)
- UniSTS:212268

Mapre1 (e-PCR), detects polymorphism
- UniSTS:527418

Mapre1 (e-PCR), detects polymorphism
- UniSTS:142942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to astral microtubule	IEA Inferred from Electronic Annotation more info
involved_in protein localization to astral microtubule	ISO Inferred from Sequence Orthology more info
involved_in protein localization to astral microtubule	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in protein localization to microtubule	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to mitotic spindle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to mitotic spindle	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cortical microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle astral microtubule end	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle astral microtubule end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated protein RP/EB family member 1

Names: APC-binding protein EB1; adenomatosis polyposis coli binding protein Eb1; end-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429678.1 → NP_001416607.1 microtubule-associated protein RP/EB family member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q66HR2

UniProtKB/TrEMBL

A6KHW5
NM_001429679.1 → NP_001416608.1 microtubule-associated protein RP/EB family member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q66HR2

UniProtKB/TrEMBL

A6KHW5
NM_001429680.1 → NP_001416609.1 microtubule-associated protein RP/EB family member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q66HR2

UniProtKB/TrEMBL

A6KHW5
NM_138509.4 → NP_612518.2 microtubule-associated protein RP/EB family member 1

See identical proteins and their annotated locations for NP_612518.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q66HR2

UniProtKB/TrEMBL

A0A8L2Q865, A6KHW5

Related

ENSRNOP00000016220.6, ENSRNOT00000016220.8

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

162679020..162707167

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235295.5 → XP_006235357.1 microtubule-associated protein RP/EB family member 1 isoform X1

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
XM_006235294.5 → XP_006235356.1 microtubule-associated protein RP/EB family member 1 isoform X1

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
XM_039104099.2 → XP_038960027.1 microtubule-associated protein RP/EB family member 1 isoform X1

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]