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    SLFN5 schlafen family member 5 [ Homo sapiens (human) ]

    Gene ID: 162394, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SLFN5provided by HGNC
    Official Full Name
    schlafen family member 5provided by HGNC
    Primary source
    HGNC:HGNC:28286
    See related
    Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SLFN5 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35243072..35273655)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36191007..36221590)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33570091..33600674)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G3 Neighboring gene Spi-C transcription factor pseudogene 2 Neighboring gene uncharacterized LOC105371932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12060 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:33570506-33571134 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:33583732-33584931 Neighboring gene NANOG hESC enhancer GRCh37_chr17:33638706-33639207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33640386-33641045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:33641707-33642365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660479-33660980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660981-33661480 Neighboring gene RING-box protein 2-like Neighboring gene schlafen family member 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12063 Neighboring gene uncharacterized LOC105371933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12064

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells. Sassano A, et al. Mol Cell Biol, 2015 Aug. PMID 26012550, Free PMC Article
    2. SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer. Xu QP, et al. J Ovarian Res, 2023 Feb 6. PMID 36747204, Free PMC Article
    3. Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery. Ding J, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35687115, Free PMC Article
    4. SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer. Martinez RS, et al. Cancer Res, 2021 Jul 1. PMID 33985973
    5. Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. Katsoulidis E, et al. J Biol Chem, 2010 Dec 17. PMID 20956525, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma.
      Title: Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma.
    2. SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
      Title: SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
    3. Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
      Title: Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
    4. SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
      Title: SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
    5. Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
      Title: Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
    6. Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
      Title: Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
    7. This is the first study to report that SLFN5 inhibits cancer migration and invasiveness in several common cancer cell lines by repressing MT1-MMP expression via the AKT/GSK-3beta/beta-catenin signalling pathway, suggesting that SLFN5 plays wide inhibitory roles in various cancers.
      Title: SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.
    8. Study results demonstrated that overexpression of SLFN5 promoted the morphology transformation of lung cancer cell line A549 from epithelial to mesenchymal, as well as migration and invasion. However, knockdown of SLFN5 resulted in the opposite results. Results suggest that SLFN5 may act as a synergist in lung cancer cell tumorigenesis and progression through beta-catenin/Snail/E-cadherin pathway.
      Title: Overexpression of SLFN5 induced the epithelial-mesenchymal transition in human lung cancer cell line A549 through β-catenin/Snail/E-cadherin pathway.
    9. Type-I IFN treatment triggers the interaction of STAT1 with SLFN5, and the resulting complex negatively controls STAT1-mediated gene transcription via interferon stimulated response elements
      Title: Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
    10. In this study population, elevated SLFN5 protein expression in patients with intestinal metaplasia correlated with progression to gastric cancer
      Title: SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with SLFN5 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19764, MGC150611, MGC150612

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    schlafen family member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330183.2 → NP_001317112.1  schlafen family member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022706, AK303632, BQ023439
      Consensus CDS
      CCDS82106.1
      UniProtKB/TrEMBL
      B4E128
      Related
      ENSP00000440537.1, ENST00000542451.1

    2. NM_144975.4 → NP_659412.3  schlafen family member 5 isoform 1

      See identical proteins and their annotated locations for NP_659412.3

      Status: VALIDATED

      Source sequence(s)
      AC022706, BC125200, BP281007, BX102817
      Consensus CDS
      CCDS32619.1
      UniProtKB/Swiss-Prot
      Q08AF2, Q08AF3, Q8WU54, Q96A82
      UniProtKB/TrEMBL
      B4E0B1
      Related
      ENSP00000299977.3, ENST00000299977.9
      Conserved Domains (3) summary
      cl21455
      Location:574 → 657
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22977
      Location:839 → 886
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl27772
      Location:34 → 332
      B3R; Poxviridae B3 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35243072..35273655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36191007..36221590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08AF3.1 GenPept UniProtKB/Swiss-Prot:Q08AF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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