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    CG8173 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8173provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030864
    Locus tag
    Dmel_CG8173
    See related
    AllianceGenome:FB:FBgn0030864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8173
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in stress-activated MAPK cascade. Is expressed in several structures, including embryonic/larval lymph gland; larval muscle system; larval somatic muscle cell; and mesoderm. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8173 in Genome Data Viewer
    Location:
    16C1-16C1; 1-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17707401..17709653, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17601434..17603686, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene par-6 Neighboring gene raskol Neighboring gene unc-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Bell O, et al. Mol Cell Biol, 2008 May. PMID 18347056, Free PMC Article
    2. Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats. Jiao B, et al. Hum Mol Genet, 2021 May 29. PMID 33749734
    3. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
    4. A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster. Hughes SE, et al. G3 (Bethesda), 2024 Apr 3. PMID 38333961, Free PMC Article
    5. Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster. Deichsel S, et al. Cells, 2024 Mar 26. PMID 38607015, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8173-PA
    NP_573239.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17707401..17709653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133011.3 → NP_573239.1  uncharacterized protein Dmel_CG8173 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VX24
      Related
      FBpp0074249
      Conserved Domains (2) summary
      smart00220
      Location:30 → 245
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:28 → 389
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VX24 Q9VX24

    Gene LinkOut

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