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    Med21 mediator complex subunit 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312849, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Med21provided by RGD
    Official Full Name
    mediator complex subunit 21provided by RGD
    Primary source
    RGD:1309836
    See related
    EnsemblRapid:ENSRNOG00000001820 AllianceGenome:RGD:1309836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Surb7
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 87.1), Muscle (RPKM 71.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med21 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (181291191..181314504)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (179560509..179583811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (180961194..180968155)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene FGFR1 oncogene partner 2 Neighboring gene transmembrane 7 superfamily member 3 Neighboring gene serine/threonine kinase 38 like Neighboring gene basic helix-loop-helix ARNT like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice. Tudor M, et al. Genes Dev, 1999 Sep 15. PMID 10500093, Free PMC Article
    2. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
    3. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149480, Free PMC Article
    4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
    5. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107895.2 → NP_001101365.2  mediator of RNA polymerase II transcription subunit 21

      See identical proteins and their annotated locations for NP_001101365.2

      Status: VALIDATED

      Source sequence(s)
      CN544042, FM087109
      UniProtKB/TrEMBL
      A6IN28, D4AA11
      Related
      ENSRNOP00000002500.6, ENSRNOT00000002500.9
      Conserved Domains (1) summary
      pfam11221
      Location:1 → 127
      Med21; Subunit 21 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      181291191..181314504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107706.2 → XP_038963634.1  mediator of RNA polymerase II transcription subunit 21 isoform X1

      UniProtKB/TrEMBL
      A6IN29
      Conserved Domains (1) summary
      pfam11221
      Location:1 → 86
      Med21; Subunit 21 of Mediator complex

    RNA

    1. XR_005503242.2 RNA Sequence

    2. XR_010065650.1 RNA Sequence

    3. XR_005503243.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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