CREB3L4 cAMP responsive element binding protein 3 like 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CREB3L4provided by HGNC
Official Full Name: cAMP responsive element binding protein 3 like 4provided by HGNC
Primary source: HGNC:HGNC:18854
See related: Ensembl:ENSG00000143578 MIM:607138; AllianceGenome:HGNC:18854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
Summary: This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression: Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q21.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (153967487..153974359)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (153104744..153111622)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (153940378..153946835)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer.
Title: AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer.
MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
Title: MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway.
The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma.
Title: The Novel Transcription Factor CREB3L4 Contributes to the Progression of Human Breast Carcinoma.
Study demonstrated that MCU1 is frequently overexpressed in breast cancer and abnormally high expression of MUC1 indicates poor prognosis. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression CREB3L4 in breast cancer tissues. Results indicated that MUC1 transcript expression may regulate tumor invasion and metastasis associated with CREB3L4 transcription.
Title: Overexpression of MUC1 predicts poor prognosis in patients with breast cancer.
CREB3L4 expression is mediated by an androgen-receptor -IRE1alpha axis, but is also directly regulated by androgen-receptor-to-androgen response elements binding.
Title: The role of CREB3L4 in the proliferation of prostate cancer cells.
AIbZIP induced by the androgen receptor axis plays a crucial role in the p21 dependent proliferation of androgen-sensitive prostate cancer cells.
Title: The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression.
In LNCaP cell lines that conditionally express the processed form of AIbZIP, downstream targets of AIbZIP include genes for protein processing, transcriptional regulation, small molecule transport, signal transduction, metabolism & cell homeostasis.
Title: Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells.
identified a novel human CREB gene (CREB4) that was 1592 bp long and encoded a protein of 395 amino acid residues
Title: Molecular cloning and characterization of a novel human cAMP response element-binding ( CREB) gene ( CREB4).
AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells.
Title: AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up-regulated by androgens in LNCaP human prostate cancer cells.
S1P cleavage of CREB4 may be suppressed by a determinant in the C-terminal region
Title: CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N&#x02009;=&#x02009;1345 young and elderly subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH63845 (e-PCR)
- UniSTS:41500

RH11825 (e-PCR)
- UniSTS:56352

D1S2463 (e-PCR)
- UniSTS:15256

RH67852 (e-PCR)
- UniSTS:91332

WI-22571 (e-PCR)
- UniSTS:25314

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclic AMP-responsive element-binding protein 3-like protein 4

Names: Androgen-Induced bZIP; CREB-4; androgen-induced basic leucine zipper protein; attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; cyclic AMP-responsive element-binding protein 4; tisp40; transcript induced in spermiogenesis protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001255978.2 → NP_001242907.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_001242907.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AY049977, DB012316

Consensus CDS

CCDS1056.1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Related

ENSP00000357596.3, ENST00000368607.8

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_001255979.2 → NP_001242908.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_001242908.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AA652478, AF394167, AF468007

Consensus CDS

CCDS1056.1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Related

ENSP00000357592.1, ENST00000368603.5

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_001255980.2 → NP_001242909.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

See identical proteins and their annotated locations for NP_001242909.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.

Source sequence(s)

AA652478, AK304665, DB012316

Consensus CDS

CCDS58029.1

UniProtKB/Swiss-Prot

Q8TEY5

Conserved Domains (1) summary

cd14689
Location:198 → 258

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_001255981.2 → NP_001242910.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

See identical proteins and their annotated locations for NP_001242910.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.

Source sequence(s)

AL358472, BX647716

Consensus CDS

CCDS58029.1

UniProtKB/Swiss-Prot

Q8TEY5

Related

ENSP00000357589.3, ENST00000368600.7

Conserved Domains (1) summary

cd14689
Location:198 → 258

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_130898.4 → NP_570968.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

See identical proteins and their annotated locations for NP_570968.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AA652478, AB052778, DB012316

Consensus CDS

CCDS1056.1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Related

ENSP00000271889.4, ENST00000271889.8

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RNA

NR_045658.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA652478, AK297703, BF681098, DB012316

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

153967487..153974359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024453343.2 → XP_024309111.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_047446827.1 → XP_047302783.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2
XM_024453344.2 → XP_024309112.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_017000372.2 → XP_016855861.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

UniProtKB/Swiss-Prot

Q8TEY5

Conserved Domains (1) summary

cd14689
Location:198 → 258

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_006711172.3 → XP_006711235.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

See identical proteins and their annotated locations for XP_006711235.1

UniProtKB/Swiss-Prot

Q8TEY5

Conserved Domains (1) summary

cd14689
Location:198 → 258

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
XM_024453346.2 → XP_024309114.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5

Conserved Domains (2) summary

TIGR00864
Location:77 → 154

PCC; polycystin cation channel protein

cd14689
Location:218 → 278

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

153104744..153111622

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054334550.1 → XP_054190525.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5
XM_054334551.1 → XP_054190526.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5
XM_054334555.1 → XP_054190530.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2
XM_054334554.1 → XP_054190529.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2
XM_054334553.1 → XP_054190528.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2
XM_054334552.1 → XP_054190527.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3DV62, Q5T4L0, Q86YW6, Q8TEY5