Atp1b4 ATPase Na+/K+ transporting family member beta 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp1b4provided by RGD
Official Full Name: ATPase Na+/K+ transporting family member beta 4provided by RGD
Primary source: RGD:620994
See related: EnsemblRapid:ENSRNOG00000007059 AllianceGenome:RGD:620994
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ac2-628
Summary: Predicted to be involved in regulation of DNA-templated transcription. Located in chromatin. Orthologous to human ATP1B4 (ATPase Na+/K+ transporting family member beta 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 131.3), Heart (RPKM 21.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq35

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (121952923..121974146)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (117087284..117108023)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (124631544..124652520)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eutherian Atp1b4 has lost its ancestral function as a Na,K-ATPase beta-subunit and associates with transcriptional coregulator Ski-interacting protein (SKIP).
Title: Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
NOT involved_in inorganic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ATP1B4

Names: ATPase, (Na+)/K+ transporting, beta 4 polypeptide; x,K-ATPase subunit beta-m; x/potassium-transporting ATPase subunit beta-m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431630.1 → NP_001418559.1 protein ATP1B4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_053381.2 → NP_445833.2 protein ATP1B4 isoform 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9R192, Q9R193

UniProtKB/TrEMBL

A6JMJ9, G3V6V5

Conserved Domains (1) summary

pfam00287
Location:90 → 348

Na_K-ATPase; Sodium / potassium ATPase beta chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

121952923..121974146

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257493.5 → XP_006257555.1 protein ATP1B4 isoform X1

Related

ENSRNOP00000009329.7, ENSRNOT00000009329.7

Conserved Domains (1) summary

pfam00287
Location:84 → 345

Na_K-ATPase; Sodium / potassium ATPase beta chain
XM_006257495.4 → XP_006257557.1 protein ATP1B4 isoform X2

UniProtKB/TrEMBL

A0A8I6A2K8

Conserved Domains (1) summary

pfam00287
Location:39 → 304

Na_K-ATPase; Sodium / potassium ATPase beta chain