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    PAQR5 progestin and adipoQ receptor family member 5 [ Homo sapiens (human) ]

    Gene ID: 54852, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PAQR5provided by HGNC
    Official Full Name
    progestin and adipoQ receptor family member 5provided by HGNC
    Primary source
    HGNC:HGNC:29645
    See related
    Ensembl:ENSG00000137819 MIM:607781; AllianceGenome:HGNC:29645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPRG
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 13.9), adrenal (RPKM 5.4) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAQR5 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69298912..69407780)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67121429..67229857)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69591251..69700119)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucuronic acid epimerase Neighboring gene RNA, 7SL, cytoplasmic 438, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69564446-69565003 Neighboring gene PAQR5 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:69597275-69598474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69610145-69610644 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69615648-69615826 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69634596-69635096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69635097-69635597 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69673828-69674009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69680714-69681358 Neighboring gene KIF23 and PAQR5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6599 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene kinesin family member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9656 Neighboring gene long intergenic non-protein coding RNA 2896 Neighboring gene ribosomal protein lateral stalk subunit P1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway. Wang L, et al. Cell Oncol (Dordr), 2023 Oct. PMID 37126128
    2. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. Charles NJ, et al. Horm Cancer, 2010 Aug. PMID 21761364, Free PMC Article
    3. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Zhu Y, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12574519, Free PMC Article
    4. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. Smith JL, et al. Steroids, 2008 Oct. PMID 18603275, Free PMC Article
    5. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Zhu Y, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601167, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
      Title: PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
    2. Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
      Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
    3. Heterologous expression of MPRG in yeast confirms its ability to function as a membrane progesterone receptor.
      Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20190

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor gamma
    Names
    mPR gamma
    membrane progesterone P4 receptor gamma
    membrane progesterone receptor gamma
    progesterone and adipoQ receptor family member 5
    progestin and adipoQ receptor family member V

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104554.2 → NP_001098024.1  membrane progestin receptor gamma

      See identical proteins and their annotated locations for NP_001098024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027237, AW779994, AY424283, BC039234
      Consensus CDS
      CCDS10232.1
      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Related
      ENSP00000453526.1, ENST00000561153.5
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    2. NM_017705.4 → NP_060175.3  membrane progestin receptor gamma

      See identical proteins and their annotated locations for NP_060175.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC026992, AC027237, AW779994, BC039234, BE747523
      Consensus CDS
      CCDS10232.1
      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Related
      ENSP00000378803.2, ENST00000395407.7
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      69298912..69407780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432749.1 → XP_047288705.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    2. XM_047432747.1 → XP_047288703.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    3. XM_047432748.1 → XP_047288704.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    4. XM_047432746.1 → XP_047288702.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    5. XM_017022360.2 → XP_016877849.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    6. XM_047432744.1 → XP_047288700.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    7. XM_017022362.2 → XP_016877851.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    8. XM_047432753.1 → XP_047288709.1  membrane progestin receptor gamma isoform X6

    9. XM_047432743.1 → XP_047288699.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    10. XM_047432751.1 → XP_047288707.1  membrane progestin receptor gamma isoform X4

    11. XM_011521720.3 → XP_011520022.1  membrane progestin receptor gamma isoform X1

      See identical proteins and their annotated locations for XP_011520022.1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    12. XM_047432750.1 → XP_047288706.1  membrane progestin receptor gamma isoform X4

    13. XM_011521727.3 → XP_011520029.1  membrane progestin receptor gamma isoform X6

      Conserved Domains (1) summary
      cl03831
      Location:43 → 204
      HlyIII; Haemolysin-III related

    14. XM_011521725.3 → XP_011520027.1  membrane progestin receptor gamma isoform X4

      Conserved Domains (1) summary
      cl03831
      Location:68 → 158
      HlyIII; Haemolysin-III related

    15. XM_047432745.1 → XP_047288701.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    16. XM_024449966.2 → XP_024305734.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 269
      HlyIII; Haemolysin-III related

    17. XM_005254495.5 → XP_005254552.1  membrane progestin receptor gamma isoform X2

      See identical proteins and their annotated locations for XP_005254552.1

      Conserved Domains (1) summary
      pfam03006
      Location:29 → 255
      HlyIII; Haemolysin-III related

    18. XM_047432752.1 → XP_047288708.1  membrane progestin receptor gamma isoform X5

    19. XM_024449967.2 → XP_024305735.1  membrane progestin receptor gamma isoform X3

      Conserved Domains (1) summary
      cl03831
      Location:112 → 202
      HlyIII; Haemolysin-III related

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      67121429..67229857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378282.1 → XP_054234257.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    2. XM_054378280.1 → XP_054234255.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    3. XM_054378281.1 → XP_054234256.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    4. XM_054378279.1 → XP_054234254.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    5. XM_054378270.1 → XP_054234245.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    6. XM_054378275.1 → XP_054234250.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    7. XM_054378271.1 → XP_054234246.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    8. XM_054378290.1 → XP_054234265.1  membrane progestin receptor gamma isoform X6

    9. XM_054378274.1 → XP_054234249.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    10. XM_054378287.1 → XP_054234262.1  membrane progestin receptor gamma isoform X4

    11. XM_054378273.1 → XP_054234248.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    12. XM_054378276.1 → XP_054234251.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    13. XM_054378272.1 → XP_054234247.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    14. XM_054378286.1 → XP_054234261.1  membrane progestin receptor gamma isoform X4

    15. XM_054378289.1 → XP_054234264.1  membrane progestin receptor gamma isoform X6

    16. XM_054378285.1 → XP_054234260.1  membrane progestin receptor gamma isoform X4

    17. XM_054378278.1 → XP_054234253.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    18. XM_054378277.1 → XP_054234252.1  membrane progestin receptor gamma isoform X1

      UniProtKB/Swiss-Prot
      Q8IXU2, Q9NXK6

    19. XM_054378283.1 → XP_054234258.1  membrane progestin receptor gamma isoform X2

    20. XM_054378288.1 → XP_054234263.1  membrane progestin receptor gamma isoform X5

    21. XM_054378284.1 → XP_054234259.1  membrane progestin receptor gamma isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXK6.2 GenPept UniProtKB/Swiss-Prot:Q9NXK6

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