RGS19 regulator of G protein signaling 19 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS19provided by HGNC
Official Full Name: regulator of G protein signaling 19provided by HGNC
Primary source: HGNC:HGNC:13735
See related: Ensembl:ENSG00000171700 MIM:605071; AllianceGenome:HGNC:13735
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GAIP; RGSGAIP
Summary: G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (64073181..64079964, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65893259..65900019, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (62704534..62711317, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS19 activates the MYH9/beta-catenin/c-Myc positive feedback loop in hepatocellular carcinoma.
Title: RGS19 activates the MYH9/β-catenin/c-Myc positive feedback loop in hepatocellular carcinoma.
Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
Title: Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.
Title: RGS19 converts iron deprivation stress into a growth-inhibitory signal.
RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect.
Title: 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.
Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity.
Title: Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.
The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23.
Title: RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.
elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
Title: Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.
cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced
Title: RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH39038 (e-PCR)
- UniSTS:88379

RGS19_2465 (e-PCR)
- UniSTS:280960

RH38937 (e-PCR)
- UniSTS:88224

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: regulator of G-protein signaling 19

Names: G alpha interacting protein; G protein signalling regulator 19; guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; regulator of G-protein signalling 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039467.2 → NP_001034556.1 regulator of G-protein signaling 19

See identical proteins and their annotated locations for NP_001034556.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.

Source sequence(s)

BC001318, BM554550

Consensus CDS

CCDS13555.1

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5

Related

ENSP00000333194.5, ENST00000332298.9

Conserved Domains (1) summary

cd08745
Location:87 → 204

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
NM_005873.3 → NP_005864.1 regulator of G-protein signaling 19

See identical proteins and their annotated locations for NP_005864.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longer transcript.

Source sequence(s)

AF285097, AL590548, BC063010

Consensus CDS

CCDS13555.1

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5

Related

ENSP00000378483.1, ENST00000395042.2

Conserved Domains (1) summary

cd08745
Location:87 → 204

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

64073181..64079964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005260183.3 → XP_005260240.1 regulator of G-protein signaling 19 isoform X3

See identical proteins and their annotated locations for XP_005260240.1

UniProtKB/TrEMBL

B4DP94, Q6I9S5

Conserved Domains (1) summary

cd08745
Location:65 → 182

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
XM_047439824.1 → XP_047295780.1 regulator of G-protein signaling 19 isoform X2

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5
XM_005260182.4 → XP_005260239.1 regulator of G-protein signaling 19 isoform X3

See identical proteins and their annotated locations for XP_005260239.1

UniProtKB/TrEMBL

B4DP94, Q6I9S5

Conserved Domains (1) summary

cd08745
Location:65 → 182

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
XM_011528485.3 → XP_011526787.1 regulator of G-protein signaling 19 isoform X2

See identical proteins and their annotated locations for XP_011526787.1

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5

Conserved Domains (1) summary

cd08745
Location:87 → 204

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
XM_011528484.3 → XP_011526786.1 regulator of G-protein signaling 19 isoform X1

UniProtKB/TrEMBL

Q6I9S5

Conserved Domains (1) summary

cd08745
Location:116 → 233

RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

65893259..65900019 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054322828.1 → XP_054178803.1 regulator of G-protein signaling 19 isoform X3

UniProtKB/TrEMBL

B4DP94, Q6I9S5
XM_054322827.1 → XP_054178802.1 regulator of G-protein signaling 19 isoform X2

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5
XM_054322826.1 → XP_054178801.1 regulator of G-protein signaling 19 isoform X2

UniProtKB/Swiss-Prot

A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

UniProtKB/TrEMBL

Q6I9S5
XM_054322829.1 → XP_054178804.1 regulator of G-protein signaling 19 isoform X3

UniProtKB/TrEMBL

B4DP94, Q6I9S5
XM_054322825.1 → XP_054178800.1 regulator of G-protein signaling 19 isoform X1

UniProtKB/TrEMBL

Q6I9S5