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    loh lonely heart [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lohprovided by FlyBase
    Official Full Name
    lonely heartprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032252
    Locus tag
    Dmel_CG6232
    See related
    AllianceGenome:FB:FBgn0032252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6232; CT19510; Dmel\CG6232; Loh
    Summary
    Involved in larval heart development and positive regulation of extracellular matrix assembly. Located in collagen-containing extracellular matrix. Is expressed in chordotonal organ; embryonic cardioblast; embryonic/larval cardial cell; embryonic/larval heart; and larval pericardial cell. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2; ectopia lentis with ectopia of pupil; and thoracic aortic aneurysm. Orthologous to human ADAMTSL4 (ADAMTS like 4) and THSD4 (thrombospondin type 1 domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See loh in Genome Data Viewer
    Location:
    31E3-31E3; 2-42 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10442534..10450080)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10442534..10450080)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45375 Neighboring gene Non-SMC element 4 Neighboring gene pickpocket 10 Neighboring gene Lysosomal alpha-mannosidase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Matricellular proteins in development: perspectives from the Drosophila heart. Volk T, et al. Matrix Biol, 2014 Jul. PMID 24726952
    2. Secreted ADAMTS-like proteins as regulators of connective tissue function. Taye N, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38284126
    3. Pericardin, a Drosophila collagen, facilitates accumulation of hemocytes at the heart. Cevik D, et al. Dev Biol, 2019 Oct 1. PMID 31228417
    4. Drosophila collagens in specialised extracellular matrices. Reinhardt M, et al. Biol Chem, 2023 Apr 25. PMID 36635942
    5. Active hematopoietic hubs in Drosophila adults generate hemocytes and contribute to immune response. Ghosh S, et al. Dev Cell, 2015 May 26. PMID 25959225, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct domains in the matricellular protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila.
      Title: Distinct domains in the matricellular protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of extracellular matrix assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lonely heart
    Names
    CG6232-PA
    CG6232-PC
    CG6232-PD
    heart
    loh-PA
    loh-PC
    loh-PD
    lonely

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10442534..10450080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169468.3 → NP_001162939.2  lonely heart, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHE3, Q8MSF8
      Conserved Domains (3) summary
      smart00209
      Location:182 → 238
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:348 → 468
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:846 → 876
      PLAC; PLAC (protease and lacunin) domain

    2. NM_135562.4 → NP_609406.2  lonely heart, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609406.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSF8, Q9VKV3
      Related
      FBpp0079619
      Conserved Domains (3) summary
      smart00209
      Location:182 → 238
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:348 → 468
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:847 → 877
      PLAC; PLAC (protease and lacunin) domain

    3. NM_001201852.1 → NP_001188781.1  lonely heart, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRI1
      Conserved Domains (3) summary
      smart00209
      Location:467 → 523
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:36 → 156
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:535 → 565
      PLAC; PLAC (protease and lacunin) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHE3 E1JHE3
    M9MRI1 M9MRI1
    Q8MSF8 Q8MSF8
    Q9VKV3 Q9VKV3

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