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    Grip71 Grip71 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grip71provided by FlyBase
    Official Full Name
    Grip71provided by FlyBase
    Primary source
    FLYBASE:FBgn0032705
    Locus tag
    Dmel_CG10346
    See related
    AllianceGenome:FB:FBgn0032705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10346; Dgp71WD; Dgrip71; Dmel\CG10346; Gp71WD; Grip71wd
    Summary
    Enables gamma-tubulin binding activity and protein-macromolecule adaptor activity. Involved in microtubule cytoskeleton organization; mitotic cell cycle; and regulation of cell cycle. Located in cytoplasm; meiotic spindle midzone; and meiotic spindle pole. Part of gamma-tubulin ring complex. Is expressed in organism. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grip71 in Genome Data Viewer
    Location:
    37A1-37A1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18708846..18711297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18708846..18711297)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jwa Neighboring gene Fas-associated factor 2 Neighboring gene Inwardly rectifying potassium channel 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44768 Neighboring gene long non-coding RNA:CR44769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. {gamma}-Tubulin ring complexes regulate microtubule plus end dynamics. Bouissou A, et al. J Cell Biol, 2009 Nov 2. PMID 19948476, Free PMC Article
    2. A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes. Romé P, et al. J Cell Biol, 2018 Oct 1. PMID 30087124, Free PMC Article
    3. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. Bouissou A, et al. EMBO J, 2014 Jan 13. PMID 24421324, Free PMC Article
    4. γ-TuRCs and the augmin complex are required for the development of highly branched dendritic arbors in Drosophila. Mukherjee A, et al. J Cell Sci, 2024 May 1. PMID 38606636, Free PMC Article
    5. Characterization of a new gammaTuRC subunit with WD repeats. Gunawardane RN, et al. Mol Biol Cell, 2003 Mar. PMID 12631720, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in bicoid mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spindle assembly involved in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin ring complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Grip71
    Names
    CG10346-PA
    Grip71-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18708846..18711297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136058.5 → NP_609902.3  Grip71 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609902.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86LC4, Q9VJ57
      Conserved Domains (3) summary
      COG2319
      Location:92 → 302
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:78 → 114
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:57 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86LC4 Q86LC4
    Q8SZD0 Q8SZD0
    Q9VJ57 Q9VJ57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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