Mettl8 methyltransferase 8, tRNA N3-cytidine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl8provided by RGD
Official Full Name: methyltransferase 8, tRNA N3-cytidineprovided by RGD
Primary source: RGD:1561059
See related: EnsemblRapid:ENSRNOG00000009382 AllianceGenome:RGD:1561059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561059; AABR07052486.1
Summary: Predicted to enable histone acetyltransferase activity; mRNA methyltransferase activity; and tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in RNA metabolic process and positive regulation of mitochondrial translation. Predicted to act upstream of or within fat cell differentiation and skeletal muscle tissue development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrial matrix. Orthologous to human METTL8 (methyltransferase 8, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 39.2), Lung (RPKM 22.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (76140465..76271367, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (55731453..55863652, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (57257394..57642096, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables mRNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (cytidine-3-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-3-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in tRNA C3-cytosine methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
NOT is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial

Names: mRNA N(3)-methylcytidine methyltransferase METTL8; methyltransferase 8, methylcytidine; methyltransferase like 8; methyltransferase-like protein 8

NP_001386442.1

EC 2.1.1.-

NP_001386443.1

EC 2.1.1.-

XP_008760176.1

EC 2.1.1.-

XP_038962292.1

EC 2.1.1.-

XP_038962293.1

EC 2.1.1.-

XP_063140473.1

EC 2.1.1.-

XP_063140474.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399513.1 → NP_001386442.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HM36, A6HM37

Related

ENSRNOP00000067958.3, ENSRNOT00000075860.3

Conserved Domains (1) summary

pfam13649
Location:190 → 293

Methyltransf_25; Methyltransferase domain
NM_001399514.1 → NP_001386443.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

76140465..76271367 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284403.1 → XP_063140473.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X4
XM_039106364.2 → XP_038962292.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X2

Related

ENSRNOP00000098991.1, ENSRNOT00000139862.1

Conserved Domains (1) summary

pfam13649
Location:202 → 305

Methyltransf_25; Methyltransferase domain
XM_008761954.4 → XP_008760176.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_008760176.1

UniProtKB/TrEMBL

A6HM36, D3ZFN6

Related

ENSRNOP00000055322.5, ENSRNOT00000058524.7

Conserved Domains (2) summary

COG0500
Location:197 → 392

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08242
Location:203 → 307

Methyltransf_12; Methyltransferase domain
XM_039106365.2 → XP_038962293.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X3

UniProtKB/TrEMBL

A6HM36

Related

ENSRNOP00000105307.1, ENSRNOT00000138988.1

Conserved Domains (1) summary

pfam13649
Location:165 → 268

Methyltransf_25; Methyltransferase domain
XM_063284404.1 → XP_063140474.1 tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X5

UniProtKB/TrEMBL

A0A096MK97

Related

ENSRNOP00000111422.1, ENSRNOT00000134483.1