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    esn espinas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    esnprovided by FlyBase
    Official Full Name
    espinasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263934
    Locus tag
    Dmel_CG43722
    See related
    AllianceGenome:FB:FBgn0263934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12833; CG12835; CG43722; Dmel\CG43722; Dm_2R:11728; Esn
    Old locus tag
    Dmel_CG12833; Dmel_CG12835
    Summary
    Predicted to enable zinc ion binding activity. Involved in dendrite self-avoidance. Is expressed in several structures, including antennal primordium; central brain primordium; head epidermis primordium; sensory neurons; and tract. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to several human genes including PRICKLE1 (prickle planar cell polarity protein 1) and PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See esn in Genome Data Viewer
    Location:
    42F1-42F2; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7086316..7127868)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2973821..3015373)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 2-1 Neighboring gene transfer RNA:Threonine-AGT 1-2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44443 Neighboring gene Cytochrome P450 9b1 Neighboring gene Cytochrome P450 9b2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Memory phase-specific genes in the Mushroom Bodies identified using CrebB-target DamID. Sgammeglia N, et al. PLoS Genet, 2023 Jun. PMID 37307281, Free PMC Article
    2. Retracing the path of planar cell polarity. Schenkelaars Q, et al. BMC Evol Biol, 2016 Apr 2. PMID 27039172, Free PMC Article
    3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
    4. The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. Matsubara D, et al. Genes Dev, 2011 Sep 15. PMID 21937715, Free PMC Article
    5. Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants. Arguello JR, et al. Elife, 2021 Mar 5. PMID 33666172, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Espinas (Esn), binds to an intracellular juxtamembrane domain of Flamingo (Fmi), and that this Fmi-Esn interplay elicits repulsion between dendritic branches of Drosophila sensory neurons
      Title: The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite self-avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    espinas
    Names
    CG43722-PA
    CG43722-PB
    CG43722-PC
    CG43722-PD
    esn-PA
    esn-PB
    esn-PC
    esn-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7086316..7127868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080251.4 → NP_524990.1  espinas, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6H1, Q8SX20, Q9U1I1, Q9V4H9
      UniProtKB/TrEMBL
      E2QC70
      Related
      FBpp0302894
      Conserved Domains (4) summary
      cd09415
      Location:244 → 302
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:307 → 362
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:367 → 425
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:143 → 239
      PET_Prickle; The PET domain of Prickle

    2. NM_165507.2 → NP_724533.1  espinas, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724533.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6H1, Q8SX20, Q9U1I1, Q9V4H9
      UniProtKB/TrEMBL
      E2QC70
      Related
      FBpp0302895
      Conserved Domains (4) summary
      cd09415
      Location:244 → 302
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:307 → 362
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:367 → 425
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:143 → 239
      PET_Prickle; The PET domain of Prickle

    3. NM_001273832.1 → NP_001260761.1  espinas, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260761.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEK5
      Conserved Domains (4) summary
      cd09415
      Location:244 → 302
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:307 → 362
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:367 → 425
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:143 → 239
      PET_Prickle; The PET domain of Prickle

    4. NM_001273831.1 → NP_001260760.1  espinas, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KED7
      Conserved Domains (4) summary
      cd09415
      Location:593 → 651
      LIM1_Prickle; The first LIM domain of Prickle
      cd09418
      Location:656 → 711
      LIM2_Prickle; The second LIM domain of Prickle
      cd09420
      Location:716 → 774
      LIM3_Prickle; The third LIM domain of Prickle
      cd09827
      Location:492 → 588
      PET_Prickle; The PET domain of Prickle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KED7 A0A0B4KED7
    A0A0B4KEK5 A0A0B4KEK5
    E2QC70 E2QC70
    Q9U1I1.1 Q9U1I1

    Gene LinkOut

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