Lk Leucokinin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lkprovided by FlyBase
Official Full Name: Leucokininprovided by FlyBase
Primary source: FLYBASE:FBgn0028418
Locus tag: Dmel_CG13480
See related: AllianceGenome:FB:FBgn0028418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13480; DLK; Dmel\CG13480; Drm-KIN; kinin; Kinin; LCK; leuc; leucokinin; Leuk; leukokinin; lk; LK; pp
Summary: Enables diuretic hormone activity and neuropeptide hormone activity. Involved in several processes, including body fluid secretion; negative regulation of feeding behavior; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular space. Is expressed in several structures, including Leucokinin neurons; ganglia; nerve; neurohemal organ; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70E2-70E2; 3-42 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14560139..14560764, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14553239..14553864, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an essential role for Lk neuropeptide in metabolic regulation of sleep, is reported.
Title: A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions.
three sets of LK neurons have different targets, but modulate the establishment of post-prandial homeostasis by regulating distinct physiological processes and behaviors such as diuresis, metabolism, organismal activity and insulin signaling
Title: Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin.
Food ingestion in Drosophila is diminished by knockdown of DH44, but not LK, and water retention is increased by LK knockdown only.
Title: Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila.
hunger induces reduction of responses to noxious heat through the Lk/Lkr signaling pathway in Drosophila.
Title: Leucokinin signaling regulates hunger-driven reduction of behavioral responses to noxious heat in Drosophila.
Disruption of Kinin signaling leads to defective air-filling during all larval stages.
Title: Endocrine regulation of airway clearance in Drosophila.
Kinin neuropeptide modulates desiccation and starvation tolerance in Drosophila melanogaster.
Title: The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster.
Data show that mutations in the leucokinin neuropeptide (leuc) and leucokinin receptor (lkr) genes cause phenotypes in which Drosophila adults have an increase in meal size and a compensatory reduction in meal frequency.
Title: The leucokinin pathway and its neurons regulate meal size in Drosophila.
Apterous is necessary for expression of the Leucokinin neuropeptide in a pair of brain neurons located in the lateral horn region of the protocerebrum
Title: Neurosecretory identity conferred by the apterous gene: lateral horn leucokinin neurons in Drosophila.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables diuretic hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables diuretic hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in body fluid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: leucokinin

Names: CG13480-PA; Leucokinin-1; Leucokinin-like; Lk-PA; drosokinin; kinin; leucokinin precursor; leukokinin; leukokinin neuropeptide; myokinin-like