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    CG8757 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8757provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036380
    Locus tag
    Dmel_CG8757
    See related
    AllianceGenome:FB:FBgn0036380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8757; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8757 in Genome Data Viewer
    Location:
    70C4-70C4; 3-41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13840197..13842240, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13833297..13835340, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene bruno 3 Neighboring gene mir-289 stem loop Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 68C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SuUR protein binds to the boundary regions separating forum domains in Drosophila melanogaster. Tchurikov NA, et al. J Biol Chem, 2004 Mar 19. PMID 14702350
    2. Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila. Nishida H, et al. Elife, 2021 Apr 27. PMID 33902813, Free PMC Article
    3. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Mangleburg CG, et al. Mol Neurodegener, 2020 Sep 29. PMID 32993812, Free PMC Article
    4. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8757-PB
    NP_648664.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13840197..13842240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140407.2 → NP_648664.2  uncharacterized protein Dmel_CG8757 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648664.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU92
      Conserved Domains (2) summary
      COG4221
      Location:1 → 252
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 247
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU92 Q9VU92

    Gene LinkOut

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