U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cph Chronophage [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31660, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cphprovided by FlyBase
    Official Full Name
    Chronophageprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029939
    Locus tag
    Dmel_CG9650
    See related
    AllianceGenome:FB:FBgn0029939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bcl11; CG9650; cph; Dmel\CG9650
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptide hormone secretion; neuroblast fate specification; and positive regulation of gene expression. Located in cytosol. Is expressed in several structures, including central brain; head epidermis primordium; proventriculus; sensory nervous system primordium; and ventral nerve cord. Used to study neurodegenerative disease; specific developmental disorder; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; immunodeficiency 49; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BCL11 transcription factor A) and BCL11B (BCL11 transcription factor B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cph in Genome Data Viewer
    Location:
    6F10-7A5; 1-20 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7137723..7241932)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7031756..7135965)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45532 Neighboring gene long non-coding RNA:CR46245 Neighboring gene long non-coding RNA:CR32730 Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants. Yamaguchi M, et al. Exp Cell Res, 2023 Dec 15. PMID 37926342
    2. Role of the BCL11A/B Homologue Chronophage (Cph) in Locomotor Behaviour of Drosophila melanogaster. Murthy S, et al. Neuroscience, 2024 Jul 23. PMID 38763224
    3. Repeat length and RNA expression level are not primary determinants in CUG expansion toxicity in Drosophila models. Le Mée G, et al. PLoS One, 2008 Jan 23. PMID 18213375, Free PMC Article
    4. The Drosophila homologue of CTIP1 (Bcl11a) and CTIP2 (Bcl11b) regulates neural stem cell temporal patterning. Fox PM, et al. Development, 2022 Sep 1. PMID 36069896, Free PMC Article
    5. Beadex, the Drosophila LIM only protein, is required for the growth of the larval neuromuscular junction. Chitre K, et al. J Neurophysiol, 2024 Aug 1. PMID 38838299

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the BCL11A/B Homologue Chronophage (Cph) in Locomotor Behaviour of Drosophila melanogaster.
      Title: Role of the BCL11A/B Homologue Chronophage (Cph) in Locomotor Behaviour of Drosophila melanogaster.
    2. Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants.
      Title: Knockdown of Chronophage in the nervous system mimics features of neurodevelopmental disorders caused by BCL11A/B variants.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    chronophage
    Names
    CG9650-PG
    CG9650-PI
    CG9650-PJ
    CG9650-PK
    CG9650-PL
    Cph-PG
    Cph-PI
    Cph-PJ
    Cph-PK
    Cph-PL

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7137723..7241932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103429.5 → NP_001096899.2  chronophage, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096899.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV12, C7LA65
      Conserved Domains (3) summary
      sd00017
      Location:1026 → 1046
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:713 → 735
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1038 → 1063
      zf-H2C2_2; Zinc-finger double domain

    2. NM_132157.2 → NP_572385.2  chronophage, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572385.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPJ3, C7LA65
      Conserved Domains (3) summary
      sd00017
      Location:957 → 977
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:644 → 666
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:969 → 994
      zf-H2C2_2; Zinc-finger double domain

    3. NM_167121.3 → NP_727173.2  chronophage, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727173.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA65, R9PY46
      Conserved Domains (3) summary
      sd00017
      Location:1024 → 1044
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:711 → 733
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1036 → 1061
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001370055.1 → NP_001356899.1  chronophage, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A499JF18, C7LA65
      Conserved Domains (3) summary
      sd00017
      Location:1030 → 1050
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:717 → 739
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1042 → 1067
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001103430.4 → NP_001096900.3  chronophage, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV11, C7LA65
      Conserved Domains (3) summary
      sd00017
      Location:1030 → 1050
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:717 → 739
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1042 → 1067
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPJ3 A0A023GPJ3
    A0A499JF18 A0A499JF18
    A8JV11 A8JV11
    A8JV12 A8JV12
    R9PY46 R9PY46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools