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    ste24c ste24c prenyl protease type I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772676, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ste24cprovided by FlyBase
    Official Full Name
    ste24c prenyl protease type Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050462
    Locus tag
    Dmel_CG9002
    See related
    AllianceGenome:FB:FBgn0050462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30462; CG33142; CG9002; Dmel\CG9002; Dmel\Ste24; Dmel\Ste24c
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in spermatogenesis. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ste24c in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16995991..16998594, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12883496..12886099, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-8 Neighboring gene long non-coding RNA:CR44377 Neighboring gene Calbindin 53E Neighboring gene uncharacterized protein Neighboring gene ste24b prenyl protease type I Neighboring gene prenyl protease type I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. Adolphsen K, et al. G3 (Bethesda), 2012 Jun. PMID 22690372, Free PMC Article
    2. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
    3. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
    4. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Pospisilik JA, et al. Cell, 2010 Jan 8. PMID 20074523
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ste24c prenyl protease type I
    Names
    CG9002-PA
    CG9002-PC
    CG9002-PD
    prenyl protease type I
    ste24c-PA
    ste24c-PC
    ste24c-PD
    NP_001027433.1
    NP_001027434.1
    NP_001261038.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16995991..16998594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032263.2 → NP_001027434.1  ste24c prenyl protease type I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV41
      Conserved Domains (3) summary
      COG0501
      Location:131 → 452
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam16491
      Location:37 → 215
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
      cl12018
      Location:229 → 441
      Peptidase_M48; Peptidase family M48

    2. NM_001274109.1 → NP_001261038.1  ste24c prenyl protease type I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV41
      Conserved Domains (3) summary
      COG0501
      Location:131 → 452
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam16491
      Location:37 → 215
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
      cl12018
      Location:229 → 441
      Peptidase_M48; Peptidase family M48

    3. NM_001032262.2 → NP_001027433.1  ste24c prenyl protease type I, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV41
      Conserved Domains (3) summary
      COG0501
      Location:131 → 452
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam16491
      Location:37 → 215
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
      cl12018
      Location:229 → 441
      Peptidase_M48; Peptidase family M48
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JV41 Q7JV41

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