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    nocte no circadian temperature entrainment [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nocteprovided by FlyBase
    Official Full Name
    no circadian temperature entrainmentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261710
    Locus tag
    Dmel_CG17255
    See related
    AllianceGenome:FB:FBgn0261710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17255; Dmel\CG17255
    Summary
    Enables mRNA 5'-UTR binding activity. Involved in entrainment of circadian clock; temperature compensation of the circadian clock; and translation reinitiation. Is active in cytosol. Is expressed in several structures, including adult chordotonal organ; chordotonal neurons; larval internal muscle motor neurons; longitudinal vein; and organism subdivision. Orthologous to human PRRC2C (proline rich coiled-coil 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nocte in Genome Data Viewer
    Location:
    9C5-9D1; 1-32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10461865..10474675, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10355898..10368708, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Neb-cGP Neighboring gene Odorant receptor 9a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. nocte Is Required for Integrating Light and Temperature Inputs in Circadian Clock Neurons of Drosophila. Chen C, et al. Curr Biol, 2018 May 21. PMID 29754901
    2. Dpr10 and Nocte are required for Drosophila motor axon pathfinding. Lobb-Rabe M, et al. Neural Dev, 2022 Oct 21. PMID 36271407, Free PMC Article
    3. A mechanosensory pathway to the Drosophila circadian clock. Simoni A, et al. Science, 2014 Jan 31. PMID 24482478
    4. Circadian clock neurons constantly monitor environmental temperature to set sleep timing. Yadlapalli S, et al. Nature, 2018 Mar 1. PMID 29466329
    5. Heating and cooling the Drosophila melanogaster clock. Maguire SE, et al. Curr Opin Insect Sci, 2015 Feb 1. PMID 26120562, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames.
      Title: RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames.
    2. A temperature input pathway from peripheral sensory organs, which depends on the gene nocte, targets specific subsets of these clock neurons to synchronize molecular and behavioral rhythms to temperature cycles. Strikingly, while nocte1 mutant flies synchronize normally to light-dark cycles at constant temperatures, the combined presence of light-dark and temperature cycles inhibits synchronization.
      Title: nocte Is Required for Integrating Light and Temperature Inputs in Circadian Clock Neurons of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 5'-UTR binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in temperature compensation of the circadian clock IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation reinitiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    no circadian temperature entrainment
    Names
    CG17255-PA
    CG17255-PB
    CG17255-PC
    CG17255-PD
    nocte-PA
    nocte-PB
    nocte-PC
    nocte-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10461865..10474675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272480.1 → NP_001259409.1  no circadian temperature entrainment, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE74
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 155
      BAT2_N; BAT2 N-terminus

    2. NM_167231.5 → NP_727425.3  no circadian temperature entrainment, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727425.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2U7
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 155
      BAT2_N; BAT2 N-terminus

    3. NM_001258685.2 → NP_001245614.1  no circadian temperature entrainment, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2U7
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 155
      BAT2_N; BAT2 N-terminus

    4. NM_132403.5 → NP_572631.3  no circadian temperature entrainment, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572631.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2U7
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 155
      BAT2_N; BAT2 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE74 M9PE74
    Q8MQI1 Q8MQI1
    Q9W2U7 Q9W2U7

    Gene LinkOut

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