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    Pgam5-2 Phosphoglycerate mutase 5-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgam5-2provided by FlyBase
    Official Full Name
    Phosphoglycerate mutase 5-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035004
    Locus tag
    Dmel_CG15874
    See related
    AllianceGenome:FB:FBgn0035004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15874; Dmel\CG15874; dPGAM5-2
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in positive regulation of mitochondrial fission. Predicted to be active in mitochondrion. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgam5-2 in Genome Data Viewer
    Location:
    60C8-60C8; 2-106 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24431344..24432733, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20318867..20320256, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prominin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy. Hashino T, et al. Exp Cell Res, 2022 Nov 1. PMID 36075447
    2. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. Imai Y, et al. PLoS Genet, 2010 Dec 2. PMID 21151955, Free PMC Article
    3. Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. Mikhaylova LM, et al. BMC Biol, 2011 May 4. PMID 21542906, Free PMC Article
    4. Burst of young retrogenes and independent retrogene formation in mammals. Pan D, et al. PLoS One, 2009. PMID 19325906, Free PMC Article
    5. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Dai H, et al. Gene, 2006 Dec 30. PMID 17101240

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglycerate mutase 5-2
    Names
    CG15874-PA
    Pgam5-2-PA
    NP_611911.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24431344..24432733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138067.2 → NP_611911.1  phosphoglycerate mutase 5-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QQ2, Q9W173
      Related
      FBpp0072263
      Conserved Domains (1) summary
      cd07067
      Location:80 → 245
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W173 Q9W173

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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