Mef2 Myocyte enhancer factor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mef2provided by FlyBase
Official Full Name: Myocyte enhancer factor 2provided by FlyBase
Primary source: FLYBASE:FBgn0011656
Locus tag: Dmel_CG1429
See related: AllianceGenome:FB:FBgn0011656
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 22.21; BEST:SD04091; C; CG1429; D-mef2; D-Mef2; D-MEF2; DMedf2; Dmef; Dmef-2; DMef-2; DMEF-2; dmef2; dMef2; dMEf2; dMEF2; Dmef2; DMef2; DMEF2; Dmel\CG1429; l(2)46CFr; mb247; mef; Mef; mef-2; Mef-2; MEF-2; mef2; MEF2; mef2c; SD04091
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including anterior midgut development; carbohydrate storage; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Is expressed in several structures, including Kenyon cell; adult pacemaker neurons; muscle cell; synaptic neuropil subdomain; and visceral mesoderm derivative. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language. Orthologous to several human genes including MEF2A (myocyte enhancer factor 2A) and MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46C4-46C7; 2-61 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9913496..9958858, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5801001..5846363, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of the Myogenic Factor Myocyte Enhancer Factor-2 Impacts Myogenesis In Vivo.
Title: Phosphorylation of the Myogenic Factor Myocyte Enhancer Factor-2 Impacts Myogenesis In Vivo.
Diversification of muscle types in Drosophila embryos.
Title: Diversification of muscle types in Drosophila embryos.
Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity.
Title: Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity.
Mef2 knockdown in dopaminergic neurons resulted in increased locomotor activity and reduced sleep, concordant with the human phenotype of ADHD.
Title: Contribution of Intellectual Disability-Related Genes to ADHD Risk and to Locomotor Activity in Drosophila.
SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K(+) and water transport molecules
Title: SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water.
Ethanol activates the Mef2. Reduced Mef2 activity in all neurons or specifically in the mushroom body decreases ethanol tolerance.
Title: Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.
The authors show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).
Title: Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
CF2 expression variations yield altered Mef2 expression levels but with correct spatio-temporal Mef2 expression patterns, it can be concluded that only the mechanism controlling expression levels is de-regulated. Here, it is proposed that CF2 regulates Mef2 expression through a Feedforward Loop circuit.
Title: CF2 transcription factor is involved in the regulation of Mef2 RNA levels, nuclei number and muscle fiber size.
Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur expression. By adding MEF2 alongside Tinman and Pannier, an expansion in expression of Hand and Sur was observed.
Title: The Drosophila Transcription Factors Tinman and Pannier Activate and Collaborate with Myocyte Enhancer Factor-2 to Promote Heart Cell Fate.
Our results show that Mef2 and possibly Sd regulate a Dl enhancer specifically expressed in the developing indirect flight muscles and that Mef2 is required for Dl expression in developing indirect flight muscles.
Title: Mef2 interacts with the Notch pathway during adult muscle development in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myocyte enhancer factor 2

Names: CG1429-PA; CG1429-PB; CG1429-PC; CG1429-PD; CG1429-PF; CG1429-PG; CG1429-PH; CG1429-PI; CG1429-PJ; CG1429-PK; CG1429-PL; DMEF2; Drosophila-myocyte enhancer factor 2; Mef2-PA; Mef2-PB; Mef2-PC; Mef2-PD; Mef2-PF; Mef2-PG; Mef2-PH; Mef2-PI; Mef2-PJ; Mef2-PK; Mef2-PL; Myocyte-enhancer factor 2; Myocyte-enhancer factor-2; complementation group C; drosophila myocyte-specific enhancer factor 2; group C; myocyte enhancer factor-2; myocyte enhancing factor 2; myocyte-specific enhancer factor 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9913496..9958858 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206067.4 → NP_995789.1 myocyte enhancer factor 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40791

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_057670.5 → NP_477018.1 myocyte enhancer factor 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477018.1

Status: REVIEWED

UniProtKB/TrEMBL

H9ZYP5

Related

FBpp0087531

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001273913.2 → NP_001260842.1 myocyte enhancer factor 2, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260842.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFI1

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001273912.1 → NP_001260841.1 myocyte enhancer factor 2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260841.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEP4

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001382026.1 → NP_001369068.1 myocyte enhancer factor 2, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3Q797

Conserved Domains (2) summary

COG5068
Location:1 → 201

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
NM_057671.5 → NP_477019.1 myocyte enhancer factor 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477019.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40791

Related

FBpp0087532

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_057673.5 → NP_477021.1 myocyte enhancer factor 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477021.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P40791

Related

FBpp0087530

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_001382027.1 → NP_001369069.1 myocyte enhancer factor 2, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3QA49

Conserved Domains (2) summary

COG5068
Location:1 → 203

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
NM_001382028.1 → NP_001369070.1 myocyte enhancer factor 2, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3Q705

Conserved Domains (2) summary

COG5068
Location:1 → 207

ARG80; Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
NM_001382029.1 → NP_001369071.1 myocyte enhancer factor 2, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3Q823

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat
NM_057672.5 → NP_477020.1 myocyte enhancer factor 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477020.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z821, P40791, Q24394, Q8MT88, Q95R70, Q95RW1, Q9U5I8

Related

FBpp0087529

Conserved Domains (2) summary

cd00265
Location:2 → 78

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam12347
Location:95 → 155

HJURP_C; Holliday junction regulator protein family C-terminal repeat

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KEP4		A0A0B4KEP4
A0A0B4KFI1		A0A0B4KFI1
A0A6M3Q705		A0A6M3Q705
A0A6M3Q797		A0A6M3Q797
A0A6M3Q823		A0A6M3Q823
A0A6M3QA49		A0A6M3QA49
P40791.3		P40791