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    TrxT Thioredoxin T [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TrxTprovided by FlyBase
    Official Full Name
    Thioredoxin Tprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029752
    Locus tag
    Dmel_CG3315
    See related
    AllianceGenome:FB:FBgn0029752
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3315; CG3315; DmelTrxT; Dmel\CG3315; DmTrxT; trxt; Trxt
    Summary
    Predicted to enable protein-disulfide reductase activity. Involved in protein folding. Located in Y chromosome. Is expressed in organism; primary spermatocyte; spermatocyte; and testis. Orthologous to several human genes including TXN (thioredoxin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TrxT in Genome Data Viewer
    Location:
    4F4-4F4; 1-11 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5310581..5311888, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5204614..5205921, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 7 Neighboring gene sans fille Neighboring gene deadhead Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures of the germline-specific Deadhead and thioredoxin T proteins from Drosophila melanogaster reveal unique features among thioredoxins. Freier R, et al. IUCrJ, 2021 Mar 1. PMID 33708404, Free PMC Article
    2. TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth. Molnar C, et al. EMBO Rep, 2024 Jul. PMID 38750349, Free PMC Article
    3. Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. Umeda-Kameyama Y, et al. J Biol Chem, 2007 Apr 13. PMID 17301052
    4. Possible function of two insect phospholipid-hydroperoxide glutathione peroxidases. Li D, et al. J Insect Physiol, 2003 Jan. PMID 12770011
    5. Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity. AlOkda A, et al. Antioxidants (Basel), 2023 Apr 17. PMID 37107319, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ThioredoxinT, a thioredoxin with testis-specific expression, has a clear association with the Y chromosome lampbrush loops ks-1 and kl-5 in primary spermatocytes
      Title: The ThioredoxinT and deadhead gene pair encode testis- and ovary-specific thioredoxins in Drosophila melanogaster.
    2. Drosophila thioredoxin can function as an anti-aging agent and as a suppressor of Parkin-associated endothelin receptor-like receptor - and poly-glutamine-induced neurotoxicity
      Title: Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Y chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin T
    Names
    CG3315-PA
    CG3315-PB
    ThioredoxinT
    TrxT-PA
    TrxT-PB
    thioredoxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5310581..5311888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297952.1 → NP_001284881.1  thioredoxin T, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IFW4, Q9W4D6
      UniProtKB/TrEMBL
      X2JID2
      Conserved Domains (1) summary
      pfam00085
      Location:13 → 105
      Thioredoxin; Thioredoxin

    2. NM_131984.1 → NP_572212.1  thioredoxin T, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572212.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IFW4, Q9W4D6
      UniProtKB/TrEMBL
      X2JID2
      Related
      FBpp0070722, FBtr0070755
      Conserved Domains (1) summary
      pfam00085
      Location:13 → 105
      Thioredoxin; Thioredoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IFW4.1 Q8IFW4
    X2JID2 X2JID2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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