mub mushroom-body expressed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mubprovided by FlyBase
Official Full Name: mushroom-body expressedprovided by FlyBase
Primary source: FLYBASE:FBgn0262737
Locus tag: Dmel_CG7437
See related: AllianceGenome:FB:FBgn0262737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.33; anon-WO0172774.35; anon-WO0172774.36; anon-WO0172774.37; CG7437; Dmel\CG7437; l(3)04093; l(3)j6B10; l(3)j8B3; MRE17; Mub; MUB
Summary: Predicted to enable mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic central brain; ganglia; and mushroom body primordium. Orthologous to several human genes including PCBP1 (poly(rC) binding protein 1); PCBP2 (poly(rC) binding protein 2); and PCBP3 (poly(rC) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 78F4-79A4; 3-47 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21844788..21932702)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21837888..21925802)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of RNA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: mushroom-body expressed

Names: CG7437-PA; CG7437-PC; CG7437-PD; CG7437-PE; CG7437-PF; CG7437-PG; CG7437-PH; CG7437-PI; CG7437-PK; CG7437-PL; CG7437-PM; CG7437-PN; Mushroom-body expressed; mRNA-like ncRNA in embryogenesis 17; mub-PA; mub-PC; mub-PD; mub-PE; mub-PF; mub-PG; mub-PH; mub-PI; mub-PK; mub-PL; mub-PM; mub-PN; mushroom bodies; mushroom body expressed; poly (rC) binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21844788..21932702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275268.1 → NP_001262197.1 mushroom-body expressed, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262197.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2A4

Conserved Domains (3) summary

cd02396
Location:103 → 173

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 91

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:262 → 332

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_001259947.1 → NP_001246876.1 mushroom-body expressed, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246876.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NGB9

Conserved Domains (3) summary

cd02396
Location:107 → 177

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 92

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:336 → 406

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_168946.4 → NP_730700.2 mushroom-body expressed, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730700.2

Status: REVIEWED

UniProtKB/TrEMBL

A4V2A4

Conserved Domains (3) summary

cd02396
Location:103 → 173

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 91

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:262 → 332

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_001259944.2 → NP_001246873.1 mushroom-body expressed, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246873.1

Status: REVIEWED

UniProtKB/TrEMBL

A4IJ59

Conserved Domains (2) summary

cd00105
Location:289 → 352

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:105 → 168

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001316446.1 → NP_001303375.1 mushroom-body expressed, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WH03

Conserved Domains (3) summary

cd02396
Location:107 → 177

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 92

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:318 → 388

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_001043154.4 → NP_001036619.1 mushroom-body expressed, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036619.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E8A7

Conserved Domains (2) summary

cd00105
Location:271 → 334

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:109 → 172

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_206423.5 → NP_996145.1 mushroom-body expressed, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996145.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95SZ9

Conserved Domains (3) summary

cd02396
Location:107 → 177

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 92

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:267 → 337

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_079484.6 → NP_524208.1 mushroom-body expressed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524208.1

Status: REVIEWED

UniProtKB/TrEMBL

P91632

Related

FBpp0078122

Conserved Domains (3) summary

cd02396
Location:107 → 177

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 92

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:289 → 359

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_001275269.1 → NP_001262198.1 mushroom-body expressed, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262198.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PIK1

Conserved Domains (3) summary

cd02396
Location:107 → 177

KH-I_PCBP_rpt2; second type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22438
Location:26 → 92

KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)

cd22439
Location:271 → 341

KH-I_PCBP_rpt3; third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
NM_001259946.2 → NP_001246875.1 mushroom-body expressed, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246875.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NEH9

Conserved Domains (2) summary

cd00105
Location:305 → 368

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:109 → 172

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001170022.3 → NP_001163493.1 mushroom-body expressed, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163493.1

Status: REVIEWED

UniProtKB/TrEMBL

A4IJ59

Conserved Domains (2) summary

cd00105
Location:289 → 352

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:105 → 168

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001259945.2 → NP_001246874.1 mushroom-body expressed, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246874.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDY6

Conserved Domains (2) summary

cd00105
Location:271 → 334

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:105 → 168

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0S0WH03		A0A0S0WH03
A4IJ59		A4IJ59
A4V2A4		A4V2A4
M9NDY6		M9NDY6
M9NEH9		M9NEH9
M9NGB9		M9NGB9
M9PIK1		M9PIK1
P91632		P91632
Q0E8A7		Q0E8A7
Q95SZ9		Q95SZ9