kug kugelei [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kugprovided by FlyBase
Official Full Name: kugeleiprovided by FlyBase
Primary source: FLYBASE:FBgn0261574
Locus tag: Dmel_CG7749
See related: AllianceGenome:FB:FBgn0261574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cad76E; CG7749; CT23445; DCad76E; Dmel\CG7749; fat; Fat-like; fat2; Fat2; ft2; ftl; Ftl; Kug; RE-A
Summary: Enables cell adhesion molecule binding activity. Involved in several processes, including digestive tract morphogenesis; establishment of planar polarity of follicular epithelium; and oogenesis. Located in several cellular components, including basal plasma membrane; cell trailing edge; and focal adhesion. Is expressed in floor cell; main body follicle cell; nurse cell; roof cell; and spermatozoon. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Orthologous to several human genes including FAT1 (FAT atypical cadherin 1) and FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76E1-76E1; 3-46 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20005301..20024607)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19998401..20017707)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
Title: Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
Data show that the atypical cadherin Fat2 directs and orchestrates transmission of the intracellular actomyosin asymmetry cue onto a tissue plane and facilitate epithelial rotation in the opposite direction.
Title: Epithelial rotation is preceded by planar symmetry breaking of actomyosin and protects epithelial tissue from cell deformations.
Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue.
Title: Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.
Concordant microtubule polarity, but not microtubule alignment, requires the atypical cadherin Fat2, which acts at an early stage to translate plus-end bias into coordinated actin-mediated collective cell migration.
Title: Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity.
Planar polarized localization of Fat2 depends on intact microtubules.Microtubule polarity depends on the atypical cadherin Fat2.
Title: Microtubule polarity predicts direction of egg chamber rotation in Drosophila.
Fat2 is required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells
Title: The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary.
fat-like gene of Drosophila is involved in the formation of tubular organs
Title: The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISM Inferred from Sequence Model more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISM Inferred from Sequence Model more info	PubMed
involved_in centripetally migrating follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in establishment of planar polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in protein localization to cell leading edge	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin-based cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell trailing edge	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: kugelei

Names: CG7749-PC; CG7749-PD; CG7749-PE; fat-like; fat2; kug-PC; kug-PD; kug-PE; kugel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20005301..20024607

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300197.1 → NP_001287126.1 kugelei, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287126.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCN4

Conserved Domains (5) summary

cd11304
Location:3173 → 3269

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:4227 → 4262

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4195 → 4225

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3953 → 4077

Laminin_G_2; Laminin G domain

cl09101
Location:309 → 390

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_140914.3 → NP_649171.3 kugelei, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649171.3

Status: REVIEWED

UniProtKB/TrEMBL

X2JCN4

Conserved Domains (5) summary

cd11304
Location:3173 → 3269

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:4227 → 4262

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4195 → 4225

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3953 → 4077

Laminin_G_2; Laminin G domain

cl09101
Location:309 → 390

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
NM_001031967.2 → NP_001027138.2 kugelei, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027138.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V252, Q95S51, Q9VW71

Conserved Domains (5) summary

cd11304
Location:3173 → 3269

Cadherin_repeat; Cadherin tandem repeat domain

smart00179
Location:4227 → 4262

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:4195 → 4225

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam02210
Location:3953 → 4077

Laminin_G_2; Laminin G domain

cl09101
Location:309 → 390

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus