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    uzip unzipped [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uzipprovided by FlyBase
    Official Full Name
    unzippedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004055
    Locus tag
    Dmel_CG3533
    See related
    AllianceGenome:FB:FBgn0004055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3533; Dmel\CG3533; nzip; Uzip; zip
    Summary
    Involved in axon guidance and axonal fasciculation. Located in plasma membrane. Is expressed in several structures, including adult head; ganglia; glial cell; gut section; and neuroblasts. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See uzip in Genome Data Viewer
    Location:
    60E12-60F1; 2-107 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25012062..25031737)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20899585..20919260)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene epithelial membrane protein Neighboring gene uncharacterized protein Neighboring gene zipper Neighboring gene Neuropeptide-like precursor 1 Neighboring gene gooseberry-neuro

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesis. Zhao DB, et al. EMBO J, 1988 Apr. PMID 3402433, Free PMC Article
    2. Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. Mansfield SG, et al. J Mol Biol, 1996 Jan 12. PMID 8568878
    3. Generation and characterization of inner photoreceptor-specific enhancer-trap lines using a novel piggyBac-Gal4 element in Drosophila. Terzioğlu Kara E, et al. Arch Insect Biochem Physiol, 2020 Jun. PMID 32285519
    4. Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila. Ding ZY, et al. Dev Dyn, 2011 Jan. PMID 21117153
    5. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. Ma J, et al. G3 (Bethesda), 2016 Aug 9. PMID 27261002, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Uzip is a novel cell adhesion molecule from the longitudinal glia regulating axon guidance.
      Title: Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    unzipped
    Names
    CG3533-PA
    CG3533-PB
    not-zipper
    uzip-PA
    uzip-PB
    zipper

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      25012062..25031737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299946.1 → NP_001286875.1  unzipped, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10379, Q960B4, Q9W0W7
      UniProtKB/TrEMBL
      A0A0B4LGL6
      Conserved Domains (1) summary
      cl26423
      Location:74 → 159
      DUF3421; Protein of unknown function (DUF3421)

    2. NM_079137.3 → NP_523861.1  unzipped, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P10379, Q960B4, Q9W0W7
      UniProtKB/TrEMBL
      A0A0B4LGL6
      Related
      FBpp0072304
      Conserved Domains (1) summary
      cl26423
      Location:74 → 159
      DUF3421; Protein of unknown function (DUF3421)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGL6 A0A0B4LGL6
    P10379.2 P10379

    Gene LinkOut

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