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    Pgant4 Polypeptide N-Acetylgalactosaminyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 261610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant4provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0051956
    Locus tag
    Dmel_CG31956
    See related
    AllianceGenome:FB:FBgn0051956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31956; CG8845; CG8845b; Dmel\CG31956; pgant4
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in several processes, including oligosaccharide biosynthetic process; protein O-linked glycosylation; and secretory granule organization. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; embryonic proventriculus; embryonic/larval midgut primordium; foregut primordium; and imaginal disc. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant4 in Genome Data Viewer
    Location:
    23F3-23F3; 2-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3472603..3475338)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3472603..3475338)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Pif1 DNA helicase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45372 Neighboring gene long non-coding RNA:CR43928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo models of mucin biosynthesis and function. Syed ZA, et al. Adv Drug Deliv Rev, 2022 May. PMID 35278522, Free PMC Article
    2. O-glycosylation regulates polarized secretion by modulating Tango1 stability. Zhang L, et al. Proc Natl Acad Sci U S A, 2014 May 20. PMID 24799692, Free PMC Article
    3. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714
    4. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    5. Multiple members of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family are essential for viability in Drosophila. Tran DT, et al. J Biol Chem, 2012 Feb 17. PMID 22157008, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that loss of PGANT4 disrupts the mucosal barrier, resulting in epithelial expression of the IL-6-like cytokine Upd3, leading to activation of JAK/STAT signaling, differentiation of cells that form the progenitor cell niche, and abnormal proliferation of progenitor cells.
      Title: Loss of the mucosal barrier alters the progenitor cell niche via Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling.
    2. PGANT4 is an O-glycosyltransferase that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1 and conferring protection from furin-mediated proteolysis
      Title: O-glycosylation regulates polarized secretion by modulating Tango1 stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 4
    Names
    CG31956-PB
    CG31956-PC
    Pgant4-PB
    Pgant4-PC
    polypeptide GalNAc transferase 4
    NP_001137779.1
    NP_722910.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3472603..3475338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164539.2 → NP_722910.2  polypeptide N-Acetylgalactosaminyltransferase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722910.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IA42, Q8IQ11
      UniProtKB/TrEMBL
      B7Z006, G7H7Z5
      Conserved Domains (4) summary
      cd02510
      Location:181 → 480
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:169 → 403
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:498 → 628
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:496 → 626
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001144307.2 → NP_001137779.1  polypeptide N-Acetylgalactosaminyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IA42, Q8IQ11
      UniProtKB/TrEMBL
      B7Z006, G7H7Z5
      Conserved Domains (4) summary
      cd02510
      Location:181 → 480
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:169 → 403
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:498 → 628
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:496 → 626
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z006 B7Z006
    Q8IA42.3 Q8IA42

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