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    JMJD4 Jumonji domain containing 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    JMJD4provided by FlyBase
    Official Full Name
    Jumonji domain containing 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032671
    Locus tag
    Dmel_CG7200
    See related
    AllianceGenome:FB:FBgn0032671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7200; Dmel\CG7200
    Summary
    Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of translational termination and protein hydroxylation. Located in cytoplasm. Is expressed in organism. Orthologous to human JMJD4 (jumonji domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See JMJD4 in Genome Data Viewer
    Location:
    36E6-36E6; 2-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18157110..18159272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18157110..18159272, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44900 Neighboring gene Protein tyrosine phosphatase 36E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Shalaby NA, et al. Sci Rep, 2018 Jan 16. PMID 29339751, Free PMC Article
    2. Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. Pinzón JH, et al. Alcohol Clin Exp Res, 2017 Dec. PMID 28940624, Free PMC Article
    3. Histone lysine demethylases in Drosophila melanogaster. Holowatyj A, et al. Fly (Austin), 2015. PMID 26207949, Free PMC Article
    4. JmjC-domain-containing proteins and histone demethylation. Klose RJ, et al. Nat Rev Genet, 2006 Sep. PMID 16983801
    5. Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila. Shalaby NA, et al. Sci Rep, 2017 Jul 12. PMID 28701701, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-oxoglutarate-dependent dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein hydroxylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jumonji domain containing 4
    Names
    CG7200-PA
    CG7200-PB
    JMJD4-PA
    JMJD4-PB
    NP_001286031.1
    NP_609870.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18157110..18159272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299102.1 → NP_001286031.1  jumonji domain containing 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ97
      UniProtKB/TrEMBL
      X2JEJ1
      Conserved Domains (2) summary
      pfam02373
      Location:199 → 299
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:172 → 221
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily

    2. NM_136026.4 → NP_609870.1  jumonji domain containing 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609870.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ97
      UniProtKB/TrEMBL
      X2JEJ1
      Related
      FBpp0080615
      Conserved Domains (2) summary
      pfam02373
      Location:199 → 299
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:172 → 221
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ97.1 Q9VJ97
    X2JEJ1 X2JEJ1

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