Sec5 Secretory 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sec5provided by FlyBase
Official Full Name: Secretory 5provided by FlyBase
Primary source: FLYBASE:FBgn0266670
Locus tag: Dmel_CG8843
See related: AllianceGenome:FB:FBgn0266670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8843; Dmel\CG8843; dsec5; Sec-5; sec5; SEC5; Sec5p
Summary: Enables small GTPase binding activity. Involved in several processes, including oogenesis; protein localization to cell junction; and vesicle-mediated transport to the plasma membrane. Located in several cellular components, including annulate lamellae; cytoplasmic vesicle; and rhabdomere. Part of exocyst and subapical complex. Is active in neuromuscular junction. Is expressed in several structures, including adult head; adult heart; embryonic/larval garland cell; female germline cell; and ganglia. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 23F3-23F3; 2-10 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3457302..3460367)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3457302..3460367)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sec5 concentrates at the sub-apical complex, indicating a role for Sec5 in the polarized epithelium.
Title: Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.
Rab11 forms a complex with Sec5. Sec5 interacts with Sec6 suggesting the exocyst is a Rab11 effector that facilitates protein transport to the apical rhabdomere in Drosophila photoreceptors
Title: Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.
Sec5, Sec6 and Sec8 act as a complex, each member dependent on the others for proper localization and function
Title: Sec6 mutations and the Drosophila exocyst complex.
The Drosophila exocyst component sec5 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane.
Title: Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.
Sec5 differentiates between two forms of vesicle trafficking: trafficking for cell growth and membrane protein insertion depend on sec5, whereas transmitter secretion does not
Title: Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists.
Germline clones of sec5 possess defects in membrane addition and the posterior positioning of the oocyte.
Title: The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0599 (e-PCR)
- UniSTS:39145

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to plasma membrane transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Golgi vesicle fusion to target membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle targeting	NAS Non-traceable Author Statement more info	PubMed
involved_in transcytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in annulate lamellae	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IEA Inferred from Electronic Annotation more info
part_of exocyst	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
part_of subapical complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: secretory 5

Names: CG8843-PA; Sec5 ortholog; Sec5-PA; sec5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3457302..3460367

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134936.3 → NP_608780.1 secretory 5 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608780.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQQ9

Related

FBpp0077208

Conserved Domains (2) summary

cd00603
Location:5 → 85

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

pfam15469
Location:193 → 383

Sec5; Exocyst complex component Sec5