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    Fbxl4 F box and leucine-rich-repeat gene 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxl4provided by FlyBase
    Official Full Name
    F box and leucine-rich-repeat gene 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030555
    Locus tag
    Dmel_CG1839
    See related
    AllianceGenome:FB:FBgn0030555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1839; dFbxl4; Dmel\CG1839; fbxl4; FBXL4
    Summary
    Involved in several processes, including negative regulation of cell communication; negative regulation of circadian sleep/wake cycle, sleep; and protein polyubiquitination. Located in neuron projection and neuronal cell body. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fbxl4 in Genome Data Viewer
    Location:
    12E5-12E5; 1-48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14234413..14237923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14128446..14131956, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 2 Neighboring gene mRNA-capping-enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A potential dimerization region of dCAMTA is critical for termination of fly visual response. Gong P, et al. J Biol Chem, 2007 Jul 20. PMID 17537720
    2. A novel family of calmodulin-binding transcription activators in multicellular organisms. Bouché N, et al. J Biol Chem, 2002 Jun 14. PMID 11925432
    3. Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States. Tabuchi M, et al. Front Neurol, 2021. PMID 33854471, Free PMC Article
    4. SnapShot: F box proteins I. Skaar JR, et al. Cell, 2009 Jun 12. PMID 19524517
    5. Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Li Q, et al. Curr Biol, 2017 Dec 4. PMID 29174887

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in negative regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of opsin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F box and leucine-rich-repeat gene 4
    Names
    CG1839-PA
    Fbxl4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14234413..14237923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132723.3 → NP_572951.1  F box and leucine-rich-repeat gene 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0S4, Q9VY46
      Related
      FBpp0073740
      Conserved Domains (4) summary
      cd09293
      Location:552 → 660
      AMN1; Antagonist of mitotic exit network protein 1
      cd00116
      Location:437 → 641
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:449 → 474
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:326 → 372
      F-box-like; F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY46 Q9VY46

    Gene LinkOut

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