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    AOX3 Aldehyde oxidase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AOX3provided by FlyBase
    Official Full Name
    Aldehyde oxidase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038349
    Locus tag
    Dmel_CG6045
    See related
    AllianceGenome:FB:FBgn0038349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6045; DmAO3; Dmel\CG6045
    Summary
    Enables aldehyde oxidase activity. Involved in acetaldehyde metabolic process. Is expressed in adult head; embryonic antennal sense organ; embryonic precursor of adult hindgut; embryonic/larval midgut; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AOX3 in Genome Data Viewer
    Location:
    88F7-88F7; 3-57 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15542748..15548188, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11368470..11373458, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Aldehyde oxidase 1 Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
    2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
    3. In Depth Exploration of the Alternative Proteome of Drosophila melanogaster. Fabre B, et al. Front Cell Dev Biol, 2022. PMID 35721519, Free PMC Article
    4. Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Monzo K, et al. Dev Biol, 2010 Apr 15. PMID 20122915, Free PMC Article
    5. The hemolymph proteome of fed and starved Drosophila larvae. Handke B, et al. PLoS One, 2013. PMID 23840627, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetaldehyde metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde oxidase 3
    Names
    AOX3-PA
    AOX3-PB
    CG6045-PA
    CG6045-PB
    NP_001303439.1
    NP_650477.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15542748..15548188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316510.1 → NP_001303439.1  aldehyde oxidase 3, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS1, Q9VF51
      Conserved Domains (6) summary
      smart01008
      Location:540 → 646
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:24 → 1238
      PLN02906; xanthine dehydrogenase
      pfam01799
      Location:80 → 153
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:688 → 1172
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:386 → 487
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
      cl19922
      Location:201 → 360
      FAD_binding_4; FAD binding domain

    2. NM_142220.2 → NP_650477.1  aldehyde oxidase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650477.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NS1, Q9VF51
      Related
      FBpp0082605
      Conserved Domains (6) summary
      smart01008
      Location:540 → 646
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:24 → 1238
      PLN02906; xanthine dehydrogenase
      pfam01799
      Location:80 → 153
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:688 → 1172
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:386 → 487
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
      cl19922
      Location:201 → 360
      FAD_binding_4; FAD binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXA6 Q8SXA6
    Q9VF51 Q9VF51

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