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    Anp Andropin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anpprovided by FlyBase
    Official Full Name
    Andropinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000094
    Locus tag
    Dmel_CG1361
    See related
    AllianceGenome:FB:FBgn0000094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    And; andropin; Cec; CEC; CG1361; Dmel\CG1361; k-9
    Summary
    Involved in defense response to Gram-positive bacterium and male-specific antibacterial humoral response. Located in extracellular region. Is expressed in ejaculatory duct. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Anp in Genome Data Viewer
    Location:
    99E2-99E2; 3-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30209948..30210382)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26035670..26036104)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cecropin A1 Neighboring gene Cecropin pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila males transfer antibacterial proteins from their accessory gland and ejaculatory duct to their mates. Lung O, et al. J Insect Physiol, 2001 Jun. PMID 11249950
    2. The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster. Samakovlis C, et al. EMBO J, 1991 Jan. PMID 1899226, Free PMC Article
    3. Drosophila cecropin as an antifungal agent. Ekengren S, et al. Insect Biochem Mol Biol, 1999 Nov. PMID 10560137
    4. The immune response in Drosophila: pattern of cecropin expression and biological activity. Samakovlis C, et al. EMBO J, 1990 Sep. PMID 2390977, Free PMC Article
    5. Mass spectrometric characterisation of the major peptides of the male ejaculatory duct, including a glycopeptide with an unusual zwitterionic glycosylation. Sturm S, et al. J Proteomics, 2021 Aug 30. PMID 34174476

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male-specific antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    andropin
    Names
    Anp-PA
    Anp-PB
    CG1361-PA
    CG1361-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30209948..30210382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300676.1 → NP_001287605.1  andropin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNE4, O16822, O16823, O16824, P21663, Q6LAI1, Q9VA90
      UniProtKB/TrEMBL
      A0A0B4LHV6
      Conserved Domains (1) summary
      pfam00272
      Location:28 → 57
      Cecropin; Cecropin family

    2. NM_079848.3 → NP_524587.1  andropin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNE4, O16822, O16823, O16824, P21663, Q6LAI1, Q9VA90
      UniProtKB/TrEMBL
      A0A0B4LHV6
      Related
      FBpp0084976
      Conserved Domains (1) summary
      pfam00272
      Location:28 → 57
      Cecropin; Cecropin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHV6 A0A0B4LHV6
    P21663.1 P21663

    Gene LinkOut

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