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    Cp110 Centriolar coiled coil protein 110kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cp110provided by FlyBase
    Official Full Name
    Centriolar coiled coil protein 110kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031191
    Locus tag
    Dmel_CG14617
    See related
    AllianceGenome:FB:FBgn0031191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14617; CG32501; CP110; DCP110; Dmel\CG14617
    Summary
    Involved in centriole elongation. Located in centriole. Is expressed in several structures, including antenna; antennal primordium; dorsal sensory complex primordium; embryonic head sensory system; and sensory nervous system primordium. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cp110 in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22482082..22487458)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21883918..21889294)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43493 Neighboring gene lethal (1) G0196 Neighboring gene long non-coding RNA:CR43962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length. Delgehyr N, et al. Curr Biol, 2012 Mar 20. PMID 22365849
    2. Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis. Ryniawec JM, et al. Curr Biol, 2023 Oct 9. PMID 37729913, Free PMC Article
    3. Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal end. Aydogan MG, et al. J Cell Sci, 2022 Jul 15. PMID 35707992, Free PMC Article
    4. Stepwise evolution of the centriole-assembly pathway. Carvalho-Santos Z, et al. J Cell Sci, 2010 May 1. PMID 20392737
    5. A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport. Safieddine A, et al. Nat Commun, 2021 Mar 1. PMID 33649340, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22484705-22485067 mobile_element_type = transposon:INE-1{}3080
    • Loc: 22486238-22486730 mobile_element_type = transposon:INE-1{}3081

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centriole elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ciliary basal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centriolar coiled coil protein 110kDa
    Names
    CG14617-PA
    CG14617-PB
    CG14617-PC
    CG14617-PD
    CG14617-PE
    CG14617-PF
    CG14617-PG
    CG14617-PH
    Cp110-PA
    Cp110-PB
    Cp110-PC
    Cp110-PD
    Cp110-PE
    Cp110-PF
    Cp110-PG
    Cp110-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22482082..22487458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038768.2 → NP_001033857.1  centriolar coiled coil protein 110kDa, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDW6, Q45EX2
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    2. NM_001298601.1 → NP_001285530.1  centriolar coiled coil protein 110kDa, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EX1, Q961V8, Q9VR58
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    3. NM_001038770.2 → NP_001033859.1  centriolar coiled coil protein 110kDa, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EX1, Q961V8, Q9VR58
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    4. NM_176775.2 → NP_788948.1  centriolar coiled coil protein 110kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788948.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EX1, Q961V8, Q9VR58
      Related
      FBpp0077045
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    5. NM_176776.3 → NP_788949.2  centriolar coiled coil protein 110kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788949.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDW6, Q45EX2
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    6. NM_001298602.1 → NP_001285531.1  centriolar coiled coil protein 110kDa, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDW6, Q45EX2
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    7. NM_001038769.2 → NP_001033858.1  centriolar coiled coil protein 110kDa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EX1, Q961V8, Q9VR58
      Conserved Domains (1) summary
      pfam16025
      Location:53 → 141
      CALM_bind; Calcium-dependent calmodulin binding

    8. NM_001272847.2 → NP_001259776.1  centriolar coiled coil protein 110kDa, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAK4, M9PI43
      Conserved Domains (1) summary
      pfam16025
      Location:54 → 142
      CALM_bind; Calcium-dependent calmodulin binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI43 M9PI43
    Q2PDW6 Q2PDW6
    Q9VR58 Q9VR58

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