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    FRG1 FSHD region gene 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FRG1provided by FlyBase
    Official Full Name
    FSHD region gene 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036964
    Locus tag
    Dmel_CG6480
    See related
    AllianceGenome:FB:FBgn0036964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6480; dFRG1; Dmel\CG6480; DmFRG1
    Summary
    Predicted to enable actin filament binding activity. Involved in heterochromatin organization. Located in cytoplasm. Used to study facioscapulohumeral muscular dystrophy. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FRG1 in Genome Data Viewer
    Location:
    77B1-77B1; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20295802..20296971, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20288902..20290071, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene golden goal Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43890 Neighboring gene antisense RNA:CR43872 Neighboring gene Peroxin 23 Neighboring gene Squamous cell carcinoma-related oncogene 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD). Jones TI, et al. PLoS One, 2016. PMID 26942723, Free PMC Article
    2. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. Neguembor MV, et al. J Mol Cell Biol, 2013 Oct. PMID 23720823
    3. Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Guan Z, et al. Learn Mem, 2011. PMID 21422168, Free PMC Article
    4. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
    5. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model. Voutyraki C, et al. Proc Natl Acad Sci U S A, 2023 Aug 15. PMID 37549261, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    FSHD region gene 1
    Names
    CG6480-PA
    FRG1-PA
    FSHD region gene 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20295802..20296971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140945.3 → NP_649202.1  FSHD region gene 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V3U4, Q9VWA8
      Related
      FBpp0074616
      Conserved Domains (1) summary
      pfam06229
      Location:72 → 260
      FRG1; FRG1-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWA8.1 Q9VWA8

    Gene LinkOut

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    Chemical Information
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