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    Ogdh Oxoglutarate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ogdhprovided by FlyBase
    Official Full Name
    Oxoglutarate dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010352
    Locus tag
    Dmel_CG11661
    See related
    AllianceGenome:FB:FBgn0010352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141810_at; alpha-KGDH-E1; anon-WO0118547.329; CG11661; Dmel\CG11661; dOgdh; DOGDH; E1; Nc73eF; Nc73EF; OGDH
    Summary
    Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in intracellular amino acid homeostasis and tricarboxylic acid cycle. Located in Z disc. Is active in mitochondrial matrix. Is expressed in several structures, including adult head; adult heart; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Used to study Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ogdh in Genome Data Viewer
    Location:
    73E1-73E1; 3-45 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16954822..16968724)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16947922..16961824)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 73D Neighboring gene Odorant-binding protein 73a Neighboring gene Ephexin Neighboring gene uncharacterized protein Neighboring gene mir-2500 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Automated assessment of cardiac dynamics in aging and dilated cardiomyopathy Drosophila models using machine learning. Melkani Y, et al. Commun Biol, 2024 Jun 7. PMID 38849449, Free PMC Article
    2. [Molecular-genetic analysis of expression features of the evolutionary-conservative neurogene Nc73EF of Drosophila melanogaster]. Gruntenko NE, et al. Genetika, 1993 Feb. PMID 8486260
    3. [Gene Nc73EF of Drosophila melanogaster encodes a protein highly homologous to E1 subunit of human 2-oxoglutarate dehydrogenase]. Gruntenko NE, et al. Genetika, 1998 Jan. PMID 9532450
    4. CRISPR/Cas9-mediated tissue-specific knockout and cDNA rescue using sgRNAs that target exon-intron junctions in Drosophila melanogaster. Chilian M, et al. STAR Protoc, 2022 Sep 16. PMID 35719725, Free PMC Article
    5. Building dialogues between clinical and biomedical research through cross-species collaborations. Chao HT, et al. Semin Cell Dev Biol, 2017 Oct. PMID 28579453, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.
      Title: Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to oxoglutarate dehydrogenase (NAD+) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular amino acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oxoglutarate dehydrogenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxoglutarate dehydrogenase
    Names
    CG11661-PA
    CG11661-PB
    CG11661-PC
    CG11661-PF
    CG11661-PG
    CG11661-PH
    CG11661-PI
    CG11661-PJ
    CG11661-PK
    Ogdh-PA
    Ogdh-PB
    Ogdh-PC
    Ogdh-PF
    Ogdh-PG
    Ogdh-PH
    Ogdh-PI
    Ogdh-PJ
    Ogdh-PK
    alpha-ketoglutarate dehydrogenase E1 subunit
    at 73EF
    neural conserved
    neural conserved at 73EF
    neural conserved at 73KF
    NP_001097629.1
    NP_001401039.1
    NP_730223.1
    NP_730224.1
    NP_730225.1
    NP_730226.3
    NP_788518.1
    NP_788519.1
    NP_788520.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16954822..16968724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168704.4 → NP_730226.3  oxoglutarate dehydrogenase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730226.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNU6
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1104
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1102
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    2. NM_168703.5 → NP_730225.1  oxoglutarate dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075023
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1007
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1005
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    3. NM_176340.3 → NP_788518.1  oxoglutarate dehydrogenase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ0
      Related
      FBpp0075027
      Conserved Domains (6) summary
      PRK09404
      Location:53 → 1016
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:268 → 530
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:654 → 865
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:872 → 1014
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
      cl06123
      Location:178 → 226
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    4. NM_176341.3 → NP_788519.1  oxoglutarate dehydrogenase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788519.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075028
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1007
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1005
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    5. NM_168702.2 → NP_730224.1  oxoglutarate dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075024
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1007
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1005
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    6. NM_001414057.1 → NP_001401039.1  oxoglutarate dehydrogenase, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Z0

    7. NM_168701.5 → NP_730223.1  oxoglutarate dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC5
      Related
      FBpp0075026
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1007
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1005
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    8. NM_001104159.3 → NP_001097629.1  oxoglutarate dehydrogenase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNU6
      Conserved Domains (5) summary
      PRK09404
      Location:53 → 1104
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:259 → 521
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:645 → 856
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:863 → 1102
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

    9. NM_176342.5 → NP_788520.2  oxoglutarate dehydrogenase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788520.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQQ0
      Conserved Domains (6) summary
      PRK09404
      Location:53 → 1016
      sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
      cd02016
      Location:268 → 530
      TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
      pfam02779
      Location:654 → 865
      Transket_pyr; Transketolase, pyrimidine binding domain
      pfam16078
      Location:51 → 86
      2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
      pfam16870
      Location:872 → 1014
      OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
      cl06123
      Location:178 → 226
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNU6 A8JNU6
    Q8IGI6 Q8IGI6
    Q8IQQ0 Q8IQQ0
    Q9VVC5 Q9VVC5

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