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Fmr1 Fragile X messenger ribonucleoprotein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37528, updated on 9-Dec-2024

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Summary

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Official Symbol: Fmr1provided by FlyBase
Official Full Name: Fragile X messenger ribonucleoprotein 1provided by FlyBase
Primary source: FLYBASE:FBgn0028734
Locus tag: Dmel_CG6203
See related: AllianceGenome:FB:FBgn0028734
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AT24755; BcDNA:GM08679; cg6203; CG6203; dfmr; dFMR; Dfmr; dfmr1; dFmr1; dFMR1; DFmr1; dFmrp; dFMRP; DFMRP; dfxr; dFXR; dfxr1; dFXR1; dFXRP; Dmel\CG6203; dmfr1; EP(3)3517; fmr; FMR; fmr1; FMR1; Fmrp; FMRp; FMRP; FXR
Summary: Enables several functions, including DEAD/H-box RNA helicase binding activity; N6-methyladenosine-containing RNA reader activity; and nucleic acid binding activity. Involved in several processes, including germ cell development; learning or memory; and regulation of nervous system development. Located in Golgi membrane; cytoplasmic ribonucleoprotein granule; and neuronal cell body. Part of RISC complex. Is expressed in several structures, including brain; germline cell; gonad; muscle cell; and somatic precursor cell. Used to study autism spectrum disorder; fragile X syndrome; and malignant pleural mesothelioma. Human ortholog(s) of this gene implicated in congenital myopathy 9A; congenital myopathy 9B; fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to several human genes including FXR1 (FMR1 autosomal homolog 1) and FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

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See Fmr1 in Genome Data Viewer

Location:: 85F10-85F12; 3-49 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10101420..10110121, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5927142..5935843, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Transposable Elements in the Brain of the Drosophila melanogaster Model for Fragile X Syndrome.
Title: Expression of Transposable Elements in the Brain of the Drosophila melanogaster Model for Fragile X Syndrome.
FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission.
Title: FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission.
The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
Title: The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.
FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function.
Title: FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function.
Fragile X premutation rCGG repeats impair synaptic growth and synaptic transmission at Drosophila larval neuromuscular junction.
Title: Fragile X premutation rCGG repeats impair synaptic growth and synaptic transmission at Drosophila larval neuromuscular junction.
Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay.
Title: Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay.
Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
Title: Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.
Title: Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.
Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period.
Title: Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period.
centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.
Title: centrocortin RNA localization to centrosomes is regulated by FMRP and facilitates error-free mitosis.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IDA Inferred from Direct Assay more info	PubMed
involved_in cellularization	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line cyst formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membraneless organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation at presynapse, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary piRNA processing	IPI Inferred from Physical Interaction more info	PubMed
NOT involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by mRNA destabilization	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fragile X messenger ribonucleoprotein 1

Names: CG6203-PA; CG6203-PB; CG6203-PC; CG6203-PD; CG6203-PE; CG6203-PF; CG6203-PG; CG6203-PH; CG6203-PI; CG6203-PJ; CG6203-PK; Fmr1-PA; Fmr1-PB; Fmr1-PC; Fmr1-PD; Fmr1-PE; Fmr1-PF; Fmr1-PG; Fmr1-PH; Fmr1-PI; Fmr1-PJ; Fmr1-PK; Fragile-X mental retardation 1; Fragile-X mental retardation protein; Fragile-X-related; cg 6203 gene product from transcript cg6203-rc; dFMR; dFmr1; drosophila fragile X mental retardation protein; fragile X; fragile X mental retardation; fragile X mental retardation 1; fragile X mental retardation gene; fragile X mental retardation protein; fragile X mental retardation protein 1; fragile X mental retardation related 1; fragile X protein; fragile X related protein; fragile X retardation 1 protein; fragile X-related; fragile x related; fragile-X

NP_001247017.1

non-AUG (CUG) translation initiation

NP_001262447.1

non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

10101420..10110121 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169324.2 → NP_731443.1 fragile X messenger ribonucleoprotein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731443.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUS7

Related

FBpp0081676

Conserved Domains (3) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:289 → 356

KH_1; KH domain

pfam12235
Location:359 → 480

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001260088.1 → NP_001247017.1 fragile X messenger ribonucleoprotein 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247017.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K618

Conserved Domains (3) summary

smart00743
Location:107 → 163

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:337 → 404

KH_1; KH domain

pfam12235
Location:407 → 528

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_169326.3 → NP_731445.1 fragile X messenger ribonucleoprotein 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081678

Conserved Domains (3) summary

smart00743
Location:21 → 77

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:251 → 318

KH_1; KH domain

pfam12235
Location:321 → 442

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001275519.1 → NP_001262448.1 fragile X messenger ribonucleoprotein 1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262448.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFN9

Conserved Domains (3) summary

smart00743
Location:21 → 77

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:251 → 314

KH_1; KH domain

pfam12235
Location:317 → 438

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001170109.2 → NP_001163580.1 fragile X messenger ribonucleoprotein 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163580.1

Status: REVIEWED

UniProtKB/TrEMBL

B3LF78

Conserved Domains (3) summary

smart00743
Location:21 → 77

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:251 → 321

KH_1; KH domain

pfam12235
Location:324 → 445

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_137801.4 → NP_611645.1 fragile X messenger ribonucleoprotein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611645.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V2M8, Q8INM7, Q8T0M0, Q8WQ60, Q95P21, Q9GSG3, Q9NFU0, Q9TVY4, Q9VH27

Related

FBpp0081675

Conserved Domains (3) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:289 → 359

KH_1; KH domain

pfam12235
Location:362 → 483

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001316514.1 → NP_001303443.1 fragile X messenger ribonucleoprotein 1, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUS7

Conserved Domains (3) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:289 → 356

KH_1; KH domain

pfam12235
Location:359 → 480

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001316515.1 → NP_001303444.1 fragile X messenger ribonucleoprotein 1, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUS7

Conserved Domains (3) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:289 → 356

KH_1; KH domain

pfam12235
Location:359 → 480

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_169325.3 → NP_731444.1 fragile X messenger ribonucleoprotein 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731444.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUS7

Related

FBpp0081677

Conserved Domains (3) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

pfam00013
Location:289 → 356

KH_1; KH domain

pfam12235
Location:359 → 480

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_169327.2 → NP_731446.1 fragile X messenger ribonucleoprotein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731446.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NFU0

Related

FBpp0081674

Conserved Domains (4) summary

smart00743
Location:59 → 115

Agenet; Tudor-like domain present in plant sequences

cd00105
Location:289 → 350

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:223 → 282

KH_1; KH domain

pfam12235
Location:352 → 473

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
NM_001275518.1 → NP_001262447.1 fragile X messenger ribonucleoprotein 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262447.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGP6

Conserved Domains (4) summary

smart00743
Location:107 → 163

Agenet; Tudor-like domain present in plant sequences

cd00105
Location:337 → 398

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam00013
Location:271 → 330

KH_1; KH domain

pfam12235
Location:400 → 521

FXMRP1_C_core; Fragile X-related 1 protein core C terminal