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    ninaD neither inactivation nor afterpotential D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ninaDprovided by FlyBase
    Official Full Name
    neither inactivation nor afterpotential Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002939
    Locus tag
    Dmel_CG31783
    See related
    AllianceGenome:FB:FBgn0002939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31783; CG5750; Dmel\CG31783; Ninad; NINAD
    Summary
    Enables scavenger receptor activity. Involved in carotenoid transport; phototransduction; and rhodopsin biosynthetic process. Predicted to be active in membrane. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; embryonic/larval fat body; epithelium; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ninaD in Genome Data Viewer
    Location:
    36E3-36E3; 2-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18081628..18083608)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18081628..18083608)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene reduced ocelli Neighboring gene Arrestin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila class B scavenger receptor NinaD-I is a cell surface receptor mediating carotenoid transport for visual chromophore synthesis. Voolstra O, et al. Biochemistry, 2006 Nov 14. PMID 17087496
    2. A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila. Kiefer C, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12136129, Free PMC Article
    3. A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism. Gomez-Diaz C, et al. Nat Commun, 2016 Jun 15. PMID 27302750, Free PMC Article
    4. Electrophysiological study of Drosophila rhodopsin mutants. Johnson EC, et al. J Gen Physiol, 1986 Nov. PMID 3097245, Free PMC Article
    5. Cellular sites of Drosophila NinaB and NinaD activity in vitamin A metabolism. Yang J, et al. Mol Cell Neurosci, 2007 May. PMID 17344064

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ninaD gene encodes a class B scavenger receptor essential for the formation of the visual chromophore; mediates the cellular uptake of carotenoids
      Title: A class B scavenger receptor mediates the cellular uptake of carotenoids in Drosophila.
    2. we provide evidence of an essential role of NinaD-I in the absorption of dietary carotenoids to support visual chromophore synthesis. Moreover, our analyses suggest a role of NinaD-I in tocopherol metabolism.
      Title: The Drosophila class B scavenger receptor NinaD-I is a cell surface receptor mediating carotenoid transport for visual chromophore synthesis.
    3. Beta-carotene is transported to the adult brain, where cellular uptake by NinaD allows cleavage by the NinaB enzyme to produce retinal
      Title: Cellular sites of Drosophila NinaB and NinaD activity in vitamin A metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables scavenger receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carotenoid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carotenoid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, visible light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neither inactivation nor afterpotential D
    Names
    CG31783-PA
    CG31783-PB
    ninaD-PA
    ninaD-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18081628..18083608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165237.2 → NP_724087.1  neither inactivation nor afterpotential D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7X2, Q8INY3
      Related
      FBpp0080584
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 474
      CD36; CD36 family

    2. NM_001201907.2 → NP_001188836.1  neither inactivation nor afterpotential D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRL5, Q8I7X2
      Conserved Domains (1) summary
      pfam01130
      Location:19 → 415
      CD36; CD36 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRL5 M9MRL5
    Q8I7X2 Q8I7X2
    Q8INY3 Q8INY3
    Q8MS21 Q8MS21

    Gene LinkOut

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