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    axo axotactin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    axoprovided by FlyBase
    Official Full Name
    axotactinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262870
    Locus tag
    Dmel_CG43225
    See related
    AllianceGenome:FB:FBgn0262870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13715; CG13717; CG18296; CG32234; CG42664; CG43225; CT1277; Dmel\CG43225
    Old locus tag
    Dmel_CG13715; Dmel_CG13717; Dmel_CG18296; Dmel_CG32234; Dmel_CG42664
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in transmission of nerve impulse. Is expressed in several structures, including adult head; ganglia; glial cell; larval central nervous system; and presumptive embryonic/larval system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See axo in Genome Data Viewer
    Location:
    64B12-64B13; 3-12 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4629604..4687317, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4629604..4687317, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Src oncogene at 64B Neighboring gene long non-coding RNA:CR45438 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45830 Neighboring gene Tubulin tyrosine ligase-like 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein. Yuan LL, et al. Science, 1999 Feb 26. PMID 10037607
    2. Identification of genetic modifiers of lifespan on a high sugar diet in the Drosophila Genetic Reference Panel. Patel SP, et al. Heliyon, 2021 Jun. PMID 34141921, Free PMC Article
    3. Inhibiting Glutamate Activity during Consolidation Suppresses Age-Related Long-Term Memory Impairment in Drosophila. Matsuno M, et al. iScience, 2019 May 31. PMID 31030182, Free PMC Article
    4. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling. Machado Almeida P, et al. Nat Commun, 2021 Oct 1. PMID 34599173, Free PMC Article
    5. Absolute Quantification of Proteins in the Eye of Drosophila melanogaster. Raghuraman BK, et al. Proteomics, 2020 Dec. PMID 32663363

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    axotactin
    Names
    CG43225-PB
    CG43225-PC
    CG43225-PD
    CG43225-PF
    CG43225-PG
    CG43225-PH
    CG43225-PI
    axo-PB
    axo-PC
    axo-PD
    axo-PF
    axo-PG
    axo-PH
    axo-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4629604..4687317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274494.1 → NP_001261423.1  axotactin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NF15, M9NFN0, M9PBP8, M9PE65, Q9VZ96
      Conserved Domains (4) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. NM_079917.5 → NP_524656.5  axotactin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524656.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XYX0
      Conserved Domains (4) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_001259702.1 → NP_001246631.1  axotactin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246631.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9NF15, M9NFN0, M9PBP8, M9PE65, Q9VZ96
      Conserved Domains (4) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    4. NM_001274493.1 → NP_001261422.1  axotactin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBP8
      Conserved Domains (5) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      pfam05466
      Location:1849 → 2012
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    5. NM_001259701.1 → NP_001246630.1  axotactin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFN0
      Conserved Domains (5) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      pfam06614
      Location:1900 → 2044
      Neuromodulin; Neuromodulin
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    6. NM_001274495.1 → NP_001261424.1  axotactin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF15
      Conserved Domains (4) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    7. NM_001259703.1 → NP_001246632.1  axotactin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF15
      Conserved Domains (4) summary
      cd00054
      Location:842 → 878
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00109
      Location:119 → 171
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02210
      Location:514 → 640
      Laminin_G_2; Laminin G domain
      cl22861
      Location:1612 → 1733
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE65.1 M9PE65
    Q9XYX0 Q9XYX0

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