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    Mis12 Mis12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mis12provided by FlyBase
    Official Full Name
    Mis12provided by FlyBase
    Primary source
    FLYBASE:FBgn0035725
    Locus tag
    Dmel_CG18156
    See related
    AllianceGenome:FB:FBgn0035725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE19545; CG18156; Dmel\CG18156; dmMis12; Mis-12; mis12; Mis12C
    Summary
    Enables kinetochore adaptor activity. Involved in mitotic chromosome movement towards spindle pole and mitotic metaphase chromosome alignment. Located in kinetochore. Part of MIS12/MIND type complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mis12 in Genome Data Viewer
    Location:
    65D5-65D5; 3-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6968035..6969048, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6961135..6962148, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Surfeit 1 Neighboring gene sugarless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit i Neighboring gene long non-coding RNA:CR32385

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Creation and testing of a new, local microtubule-disruption tool based on the microtubule-severing enzyme, katanin p60. Advani S, et al. Cytoskeleton (Hoboken), 2018 Dec. PMID 30176123, Free PMC Article
    2. The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes. Głuszek AA, et al. J Cell Biol, 2015 Dec 21. PMID 26668329, Free PMC Article
    3. Network of protein interactions within the Drosophila inner kinetochore. Richter MM, et al. Open Biol, 2016 Feb. PMID 26911623, Free PMC Article
    4. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Liu Y, et al. Open Biol, 2016 Feb. PMID 26911624, Free PMC Article
    5. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Venkei Z, et al. Genetics, 2011 Jan. PMID 20980244, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mis12
    Names
    CG18156-PA
    Mis12-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6968035..6969048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139809.3 → NP_648066.1  Mis12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648066.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VS01
      Related
      FBpp0076645
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS01 Q9VS01

    Gene LinkOut

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