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    Sol1 Sol1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sol1provided by FlyBase
    Official Full Name
    Sol1provided by FlyBase
    Primary source
    FLYBASE:FBgn0085431
    Locus tag
    Dmel_CG34402
    See related
    AllianceGenome:FB:FBgn0085431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17756; CG17793; CG31218; CG34402; CG4940; CT39356; Dmel\CG34402; dSol-1; sol-1; SOL-1
    Old locus tag
    CG17793; CG31218; CG4940; Dmel_CG17793; Dmel_CG31218; Dmel_CG4940
    Summary
    Enables channel activator activity. Involved in positive regulation of glutamatergic synaptic transmission and presynaptic modulation of chemical synaptic transmission. Located in presynaptic membrane. Is expressed in adult fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sol1 in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12386249..12402902)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8211971..8228624)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase D11 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 9f3 Neighboring gene DNA ligase 3 Neighboring gene Cytochrome P450 9f2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Walker CS, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16818875, Free PMC Article
    2. Rapid homeostatic modulation of transsynaptic nanocolumn rings. Muttathukunnel P, et al. Proc Natl Acad Sci U S A, 2022 Nov 8. PMID 36322725, Free PMC Article
    3. The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation. Kiragasi B, et al. Proc Natl Acad Sci U S A, 2020 Oct 13. PMID 32973097, Free PMC Article
    4. A genome-wide analysis of courting and mating responses in Drosophila melanogaster females. Lawniczak MK, et al. Genome, 2004 Oct. PMID 15499404
    5. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.
      Title: The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of positive regulation of glutamate secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sol1
    Names
    CG34402-PC
    CG34402-PD
    CG34402-PE
    Sol1-PC
    Sol1-PD
    Sol1-PE
    suppressor of lurcher movement defect-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12386249..12402902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104286.2 → NP_001097756.1  Sol1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQY3, Q4V4F1
      Conserved Domains (1) summary
      cd00041
      Location:527 → 644
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. NM_001300376.1 → NP_001287305.1  Sol1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q15KK8, Q4V4F1
      Conserved Domains (1) summary
      cd00041
      Location:514 → 631
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    3. NM_001104288.2 → NP_001097758.1  Sol1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097758.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V495
      Conserved Domains (1) summary
      cd00041
      Location:318 → 435
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JQY3 A8JQY3
    Q15KK8 Q15KK8
    Q4V495 Q4V495

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.