Cdk12 Cyclin-dependent kinase 12 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk12provided by FlyBase
Official Full Name: Cyclin-dependent kinase 12provided by FlyBase
Primary source: FLYBASE:FBgn0037093
Locus tag: Dmel_CG7597
See related: AllianceGenome:FB:FBgn0037093
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC017581; anon-WO0140519.165; cdk12; CDK12; cg7597; CG7597; dCdk12; dCDK12; Dmel\CG7597; gi24668141
Summary: Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in positive regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Located in nuclear chromosome and polytene chromosome puff. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder; hepatocellular carcinoma; intellectual disability; and prostate carcinoma. Orthologous to several human genes including CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 78D4-78D5; 3-47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21516306..21522684)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21509406..21515784)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.
Title: Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.
CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.
Title: Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.
The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.
Title: The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Cyclin-dependent kinase 12

Names: CG7597-PA; CG7597-PB; CG7597-PC; Cdk12-PA; Cdk12-PB; Cdk12-PC

NP_001262167.1

EC 2.7.11.22

EC 2.7.11.23

NP_649325.2

EC 2.7.11.22

EC 2.7.11.23

NP_730643.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21516306..21522684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168912.2 → NP_730643.1 Cyclin-dependent kinase 12, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730643.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T9E1, Q95SE1, Q9VP22

UniProtKB/TrEMBL

M9PG50

Related

FBpp0078013

Conserved Domains (2) summary

smart00220
Location:804 → 1098

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:796 → 1098

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_141068.4 → NP_649325.2 Cyclin-dependent kinase 12, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649325.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T9E1, Q95SE1, Q9VP22

UniProtKB/TrEMBL

M9PG50

Related

FBpp0078014

Conserved Domains (2) summary

smart00220
Location:804 → 1098

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:796 → 1098

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_001275238.1 → NP_001262167.1 Cyclin-dependent kinase 12, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262167.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8T9E1, Q95SE1, Q9VP22

UniProtKB/TrEMBL

M9PG50

Conserved Domains (2) summary

smart00220
Location:804 → 1098

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:796 → 1098

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12