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    Eip93F Ecdysone-induced protein 93F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eip93Fprovided by FlyBase
    Official Full Name
    Ecdysone-induced protein 93Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264490
    Locus tag
    Dmel_CG18389
    See related
    AllianceGenome:FB:FBgn0264490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02059370.58; CG18389; Dmel\CG18389; E93; Eip93; eip93f; eip93F; Eip93f; l(3)93; l(3)ry93; lincRNA.833; psg11
    Summary
    Predicted to enable DNA binding activity. Involved in cellular response to hypoxia. Located in nucleus. Is expressed in several structures, including adult antennal olfactory receptor neurons; central nervous system; midgut; organism subdivision; and salivary gland. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor) and LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eip93F in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21949114..22014539)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17774836..17840261)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Quiescin sulfhydryl oxidase 3 Neighboring gene Quiescin sulfhydryl oxidase 2 Neighboring gene Testicular haploid expressed gene Neighboring gene Isocitrate dehydrogenase 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal E93 is required for adaptation to adult metabolism and behavior. Yip C, et al. Mol Metab, 2024 Jun. PMID 38621602, Free PMC Article
    2. Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals. Takayanagi-Kiya S, et al. Int J Mol Sci, 2017 Jan 25. PMID 28125049, Free PMC Article
    3. The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation. Long S, et al. Insect Sci, 2024 Feb. PMID 37370257
    4. Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila. Ling L, et al. Sci Adv, 2023 Feb 17. PMID 36800429, Free PMC Article
    5. Mutants for Drosophila Isocitrate Dehydrogenase 3b Are Defective in Mitochondrial Function and Larval Cell Death. Duncan DM, et al. G3 (Bethesda), 2017 Mar 10. PMID 28104670, Free PMC Article

    See all (167) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal E93 is required for adaptation to adult metabolism and behavior.
      Title: Neuronal E93 is required for adaptation to adult metabolism and behavior.
    2. E93 promotes transcription of RHG genes to initiate apoptosis during Drosophila salivary gland metamorphosis.
      Title: E93 promotes transcription of RHG genes to initiate apoptosis during Drosophila salivary gland metamorphosis.
    3. Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.
      Title: Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.
    4. Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
      Title: Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
    5. Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.
      Title: Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.
    6. Wing-specific knockdown of the E93 gene in Drosophila impedes wing development.
      Title: Transcription factor E93 regulates wing development by directly promoting Dpp signaling in Drosophila.
    7. This study identified E93, a steroid-hormone-induced transcription factor that downregulates phosphatidylinositol 3-kinase (PI3K) levels to activate autophagy for elimination of mushroom body (MB) neuroblasts.
      Title: E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy.
    8. Autophagy and caspase activity are induced by 20E and predominantly transduced by E93 in the remodeling fat body of Drosophila.
      Title: E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body.
    9. Here, we show that the transcription factor E93 is the key determinant that promotes adult metamorphosis in both hemimetabolous and holometabolous insects, thus acting as the universal adult specifier.
      Title: Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects.
    10. E93 likely controls the responsiveness of many other target genes because it is required broadly for patterning during metamorphosis.
      Title: Control of target gene specificity during metamorphosis by the steroid response gene E93.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ecdysone-induced protein 93F
    Names
    CG18389-PA
    CG18389-PB
    CG18389-PC
    E3
    Eip93F-PA
    Eip93F-PB
    Eip93F-PC
    lethal (3) ry93

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21949114..22014539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104395.2 → NP_001097865.1  Ecdysone-induced protein 93F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU18
      Conserved Domains (1) summary
      pfam05225
      Location:794 → 839
      HTH_psq; helix-turn-helix, Psq domain

    2. NM_143745.3 → NP_652002.2  Ecdysone-induced protein 93F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652002.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD60
      Related
      FBpp0083567
      Conserved Domains (1) summary
      pfam05225
      Location:771 → 816
      HTH_psq; helix-turn-helix, Psq domain

    3. NM_001275888.1 → NP_001262817.1  Ecdysone-induced protein 93F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHV1
      Conserved Domains (1) summary
      pfam05225
      Location:771 → 816
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHV1 A0A0B4KHV1
    Q24079 Q24079
    Q7YU18 Q7YU18
    Q9VD60 Q9VD60

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