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    TRAM TRAM [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31042, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRAMprovided by FlyBase
    Official Full Name
    TRAMprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040340
    Locus tag
    Dmel_CG11642
    See related
    AllianceGenome:FB:FBgn0040340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11642; CG18830; Dmel\CG11642; EG:BACR7A4.5; Tram
    Summary
    Predicted to be involved in protein insertion into ER membrane. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa primordium; dorsal epidermis primordium; and epithelium. Orthologous to several human genes including TRAM1 (translocation associated membrane protein 1) and TRAM1L1 (translocation associated membrane protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TRAM in Genome Data Viewer
    Location:
    1D2-1D2; 1-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (935232..937822)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (829265..831855)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 22 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mus81 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A paired-end sequencing strategy to map the complex landscape of transcription initiation. Ni T, et al. Nat Methods, 2010 Jul. PMID 20495556, Free PMC Article
    2. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. Bauer R, et al. EMBO J, 2009 Dec 2. PMID 19834458, Free PMC Article
    3. Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA. Ragheb R, et al. Sci Rep, 2017 Nov 24. PMID 29176735, Free PMC Article
    4. E3 ubiquitin ligase-mediated regulation of vertebrate ocular development; new insights into the function of SIAH enzymes. Piedade WP, et al. Biochem Soc Trans, 2021 Feb 26. PMID 33616626, Free PMC Article
    5. Targeted substrate degradation by Kelch controls the actin cytoskeleton during ring canal expansion. Hudson AM, et al. Development, 2019 Jan 2. PMID 30559276, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAM
    Names
    CG11642-PA
    CG11642-PB
    CG11642-PC
    CG11642-PD
    CG11642-PE
    TRAM-PA
    TRAM-PB
    TRAM-PC
    TRAM-PD
    TRAM-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      935232..937822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166867.2 → NP_726711.1  TRAM, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L3, Q9W5C2
      Related
      FBpp0070162
      Conserved Domains (2) summary
      smart00724
      Location:124 → 290
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:52 → 121
      TRAM1; TRAM1-like protein

    2. NM_166866.2 → NP_726710.1  TRAM, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L3, Q9W5C2
      Related
      FBpp0070163
      Conserved Domains (2) summary
      smart00724
      Location:124 → 290
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:52 → 121
      TRAM1; TRAM1-like protein

    3. NM_001272186.1 → NP_001259115.1  TRAM, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L3, Q9W5C2
      Conserved Domains (2) summary
      smart00724
      Location:124 → 290
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:52 → 121
      TRAM1; TRAM1-like protein

    4. NM_001258527.1 → NP_001245456.1  TRAM, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L3, Q9W5C2
      Conserved Domains (2) summary
      smart00724
      Location:124 → 290
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:52 → 121
      TRAM1; TRAM1-like protein

    5. NM_166868.1 → NP_726712.1  TRAM, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1L3, Q9W5C2
      Related
      FBpp0070164, FBtr0070169
      Conserved Domains (2) summary
      smart00724
      Location:124 → 290
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:52 → 121
      TRAM1; TRAM1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1L3 Q9U1L3
    Q9W5C2 Q9W5C2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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