cic capicua [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cicprovided by FlyBase
Official Full Name: capicuaprovided by FlyBase
Primary source: FLYBASE:FBgn0262582
Locus tag: Dmel_CG43122
See related: AllianceGenome:FB:FBgn0262582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG43122; CG5060; CG5067; Cic; CiC; CIC; cics; Dmel\CG43122; E(Dl)D49; fet
Old locus tag: Dmel_CG5060; Dmel_CG5067
Summary: Enables DNA-binding transcription factor binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; dorsal appendage formation; and regionalization. Located in cytosol and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; clypeo-labral primordium; eye disc anterior to the morphogenetic furrow; and head epidermis primordium. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92D9-92E2; 3-68 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20252770..20303942)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16078492..16129664)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis.
Title: Noncanonical function of Capicua as a growth termination signal in Drosophila oogenesis.
Capicua is a fast-acting transcriptional brake.
Title: Capicua is a fast-acting transcriptional brake.
Activation-induced substrate engagement in ERK signaling.
Title: Activation-induced substrate engagement in ERK signaling.
Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua.
Title: Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua.
Cic regulated spatially restricted expression of Toll/IL-1 signaling targets in Drosophila embryogenesis.
Title: Capicua controls Toll/IL-1 signaling targets independently of RTK regulation.
We have thus uncovered a previously unknown mechanism of down-regulation of Cic activity by Mnb and Wap, which operates independently from the ERK-mediated control of Cic. Therefore, Cic functions as an integrator of upstream signals that are essential for tissue patterning and organ growth
Title: Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.
Analysis of CSN1b mutant phenotypes revealed a requirement for the COP9 signalosome to prevent ectopic expression of Epidermal growth factor receptor (EGFR) target genes. It does so by protecting Capicua, a transcriptional repressor of EGFR target genes, from EGFR pathway-dependent ubiquitylation.
Title: COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.
Data indicate that the HMG-box of Capicua (CIC) does not bind DNA alone but instead requires a distant motif (referred to as C1) present at the C-terminus of all CIC proteins.
Title: A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.
These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells
Title: EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes.
Thus, Cic proteins employ distinct repressor mechanisms that are associated with discrete structural changes in the evolutionary history of this protein family.
Title: Origins of context-dependent gene repression by capicua.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 20266571-20272984 mobile_element_type = transposon:Burdock{}1394

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal specification of dorsal/ventral axis, oocyte, soma encoded	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in torso signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: capicua

Names: CG43122-PA; CG43122-PB; CG43122-PC; CG43122-PD; CG43122-PG; CG43122-PH; cic-PA; cic-PB; cic-PC; cic-PD; cic-PG; cic-PH; enhancer of delta D49; fettucine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20252770..20303942

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275826.1 → NP_001262755.1 capicua, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262755.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGD7, D0IQJ5

Conserved Domains (2) summary

cd01388
Location:1231 → 1302

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam16090
Location:349 → 431

DUF4819; Domain of unknown function (DUF4819)
NM_001260274.2 → NP_001247203.1 capicua, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247203.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K698, D0IQJ5

Conserved Domains (2) summary

cd01388
Location:1227 → 1298

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam16090
Location:349 → 431

DUF4819; Domain of unknown function (DUF4819)
NM_001260275.2 → NP_001247204.2 capicua, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247204.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6D6

Conserved Domains (1) summary

cd01388
Location:337 → 408

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001104373.2 → NP_001097843.1 capicua, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097843.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JR51, B5RIQ9, Q29R05, Q9U1H0, Q9VDN9

Conserved Domains (1) summary

cd01388
Location:489 → 560

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_080253.4 → NP_524992.1 capicua, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U1H0

Related

FBpp0293563

Conserved Domains (1) summary

cd01388
Location:489 → 560

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001260273.2 → NP_001247202.1 capicua, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247202.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K778

Conserved Domains (1) summary

cd01388
Location:489 → 560

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...