dom domino [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: domprovided by FlyBase
Official Full Name: dominoprovided by FlyBase
Primary source: FLYBASE:FBgn0020306
Locus tag: Dmel_CG9696
See related: AllianceGenome:FB:FBgn0020306
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 27/4; anon-WO0172774.190; CG9696; dDom; dEP400; Dmel\CG9696; Dom; DOM; DOM-A; DomA; Domino; l(2)81/8; l(2)k02704; l(2)k08108; p400
Summary: Enables ATP-dependent H2AZ histone chaperone activity. Involved in several processes, including chromatin remodeling; dendrite guidance; and male germ-line stem cell population maintenance. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including adult optic lobe; embryonic/larval salivary gland; eye disc posterior to the morphogenetic furrow; germline cell; and presumptive embryonic/larval system. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 57D11-57D12; 2-94 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21323430..21341847)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17210935..17229352)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
Title: Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster.
Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms.
Title: Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms.
Study identified the Drosophila SWI2/SNF2 protein DOMINO (DOM) as a key regulator of circadian behavior. Depletion of DOM in circadian neurons eliminates morning anticipatory activity under light dark cycle and impairs behavioral rhythmicity in constant darkness. Interestingly, the two major splice variants of DOM, DOM-A and DOM-B have distinct circadian functions.
Title: Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance.
Dom acts pleiotropically as a positive effector of Notch signaling and a repressor of proliferation.
Title: A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster.
DOM is implicated in developmental gene activation
Title: Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.
the roles of dom and iswi in germ line stem cell and somatic stem cell regulation
Title: Stem cell self-renewal controlled by chromatin remodeling factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent H2AZ histone chaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte proliferation	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: domino

Names: CG9696-PA; CG9696-PD; CG9696-PE; CG9696-PG; Domino-A; dom-PA; dom-PD; dom-PE; dom-PG; domino DNA dependent ATPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21323430..21341847

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299747.1 → NP_001286676.1 domino, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286676.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFX8, B5RJR0

Conserved Domains (6) summary

smart00573
Location:543 → 614

HSA; domain in helicases and associated with SANT domains

cd00046
Location:969 → 1108

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:952 → 1238

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1692 → 1806

Helicase_C; Helicase conserved C-terminal domain

pfam14851
Location:824 → 868

FAM176; FAM176 family

cl22451
Location:674 → 831

ASF1_hist_chap; ASF1 like histone chaperone
NM_080094.4 → NP_524833.2 domino, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524833.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YZ94, Q95TN6, Q968U6, Q9I7V8, Q9NDJ2

UniProtKB/TrEMBL

B5RJR0

Related

FBpp0071529

Conserved Domains (6) summary

smart00573
Location:508 → 579

HSA; domain in helicases and associated with SANT domains

cd00046
Location:934 → 1073

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:917 → 1203

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1657 → 1771

Helicase_C; Helicase conserved C-terminal domain

pfam14851
Location:789 → 833

FAM176; FAM176 family

cl22451
Location:639 → 796

ASF1_hist_chap; ASF1 like histone chaperone
NM_166446.3 → NP_726065.1 domino, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726065.1

Status: REVIEWED

UniProtKB/TrEMBL

B5RJR0, Q8MLW2

Related

FBpp0071528

Conserved Domains (6) summary

smart00573
Location:508 → 579

HSA; domain in helicases and associated with SANT domains

cd00046
Location:934 → 1073

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:917 → 1203

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1657 → 1771

Helicase_C; Helicase conserved C-terminal domain

pfam14851
Location:789 → 833

FAM176; FAM176 family

cl22451
Location:639 → 796

ASF1_hist_chap; ASF1 like histone chaperone
NM_176244.3 → NP_788424.1 domino, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788424.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NDJ2

Related

FBpp0071530

Conserved Domains (6) summary

smart00573
Location:508 → 579

HSA; domain in helicases and associated with SANT domains

cd00046
Location:934 → 1073

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:917 → 1203

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:1657 → 1771

Helicase_C; Helicase conserved C-terminal domain

pfam14851
Location:789 → 833

FAM176; FAM176 family

cl22451
Location:639 → 769

ASF1_hist_chap; ASF1 like histone chaperone