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    Zmynd10 Zinc finger MYND-type containing 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmynd10provided by FlyBase
    Official Full Name
    Zinc finger MYND-type containing 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0266709
    Locus tag
    Dmel_CG11253
    See related
    AllianceGenome:FB:FBgn0266709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11253; Dmel\CG11253
    Summary
    Involved in several processes, including cilium assembly; flagellated sperm motility; and sensory perception of sound. Located in cytoplasm and neuronal cell body. Is expressed in Johnston organ neurons; chordotonal neurons; chordotonal organ precursor cell; and spermatogonium. Used to study primary ciliary dyskinesia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zmynd10 in Genome Data Viewer
    Location:
    69F5-69F5; 3-39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13024763..13026437, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13017863..13019537, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S12 Neighboring gene long non-coding RNA:CR45172 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Moore DJ, et al. Am J Hum Genet, 2013 Aug 8. PMID 23891471, Free PMC Article
    2. Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization. Newton FG, et al. Dev Cell, 2012 Jun 12. PMID 22698283, Free PMC Article
    3. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
    4. Imaging cilia in Drosophila melanogaster. Vieillard J, et al. Methods Cell Biol, 2015. PMID 25837397
    5. Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila. Li L, et al. Nat Commun, 2020 Nov 5. PMID 33154379, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proprioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in dynein axonemal particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger MYND-type containing 10
    Names
    CG11253-PA
    ZMYND10 homolog
    Zmynd10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13024763..13026437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140368.2 → NP_648625.1  zinc finger MYND-type containing 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ82, Q9VU41
      Related
      FBpp0075628
      Conserved Domains (1) summary
      pfam01753
      Location:429 → 448
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU41.1 Q9VU41

    Gene LinkOut

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